Liquid chromatography/Fourier transform ion cyclotron resonance mass spectrometry (LC-FTICR MS): an early overview

被引：0
作者：
Wolfgang Schrader
Heinz-Werner Klein
机构：
[1] Max-Planck-Institut für Kohlenforschung,
来源：
Analytical and Bioanalytical Chemistry | 2004年 / 379卷
关键词：
Liquid chromatography; Fourier-transform ion cyclotron resonance mass spectrometry; LC–FTICR; Proteomics; High-resolution mass spectrometry;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Fourier-transform ion cyclotron resonance mass spectrometry has developed into one of the most powerful analytical techniques. This unique technique enables acquisition of high-resolution mass spectra with high accuracy, which in turn enables determination of the elemental composition of the analyzed compounds. Coupling with liquid chromatography affords a separation technique with a high-resolution “detector” which can be used to investigate very complex matrices. In this review some important instrumental developments are described and applications are presented; these show the advantages and disadvantages of this combination.
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页码：1013 / 1024
页数：11
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