Bovine viral diarrhea virus non-structural protein NS4B induces autophagosomes in bovine kidney cells

被引：0
作者：
Yuto Suda
Shin Murakami
Taisuke Horimoto
机构：
[1] The University of Tokyo,Department of Veterinary Microbiology, Graduate School of Agricultural and Life Sciences
[2] National Agriculture and Food Research Organization,Division of Viral Disease and Epidemiology, National Institute of Animal Health
来源：
Archives of Virology | 2019年 / 164卷
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摘要：
Bovine viral diarrhea virus (BVDV) is an important pathogen in cattle that causes economic losses in livestock industries. Autophagy is an essential cell system for the maintenance of homeostasis and is induced by various triggers, including infection by viruses. BVDV infection leads to autophagy in order to enhance its replication in cells. In this study, we investigated the effect of BVDV non-structural proteins on the induction of autophagosomes. We found that NS4B alone could induce autophagosomes, suggesting a novel and important function of NS4B in BVDV replication.
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页码：255 / 260
页数：5
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