Excessive hepatic copper accumulation in jaundiced rats fed a high-copper diet

被引：0
作者：
Yu S. [1 ]
Van Der Meer R. [2 ]
Beynen A.C. [1 ]
机构：
[1] Department of Nutrition, Faculty of Veterinary Medicine, Utrecht University, Utrecht
[2] Department of Nutrition, Netherlands Institute for Dairy Research, Ede
来源：
Biological Trace Element Research | 2002年 / 88卷 / 3期
关键词：
Bile; Copper; Jaundice; Rats;
D O I：
10.1385/BTER:88:3:255
中图分类号：
学科分类号：
摘要：
The response of copper metabolism to dietary copper challenge was investigated in jaundiced rats with elevated plasma concentrations of conjugated bilirubin as a result of impaired canicular transport of bilirubin glucuronides. Control and jaundiced rats were fed purified diets with either normal (64 μmol Cu/kg) or high (640 μmol Cu/kg) concentration of added copper. Copper loading produced a greater increase in hepatic copper concentrations in the jaundiced than in control rats. The greater dietary-copper-induced increase in hepatic copper in the jaundiced rats can be explained by the observed smaller rise in biliary copper excretion and a greater efficiency of dietary copper absorption. In individual rats, there was a positive relationship between hepatic copper concentrations and biliary copper concentrations. It is suggested that not the transport of copper from liver cells to bile but that from plasma to bile is diminished in the jaundiced rats. The elevated plasma copper concentrations in the jaundiced rats may support this suggestion.
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页码：255 / 269
页数：14
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