Interleukin-1B and interleukin-1 receptor antagonist gene polymorphisms in Greek multiple sclerosis (MS) patients with bout-onset MS

被引:0
作者
Konstantinos Aggelakis
Fani Zacharaki
Efthimios Dardiotis
Georgia Xiromerisiou
Vana Tsimourtou
Styliani Ralli
Maria Gkaraveli
Dimitris Bourpoulas
Paraskevi Rodopoulou
Alexandros Papadimitriou
Georgios Hadjigeorgiou
机构
[1] University of Thessaly,Department of Neurology, Faculty of Medicine
[2] Institute of Biomedical Research and Technology,Department of Biomathematics, Faculty of Medicine
[3] University of Thessaly,undefined
来源
Neurological Sciences | 2010年 / 31卷
关键词
Multiple sclerosis; Interleukin; Association; Polymorphism; Gene;
D O I
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学科分类号
摘要
We investigated the association of specific polymorphisms of the interleukin IL-1b (AvaI −511 and TaqI +3,953) and IL-1 receptor antagonist (IL-1RN) (a variable number of tandem repeats; VNTR) genes with both the susceptibility to and the clinical characteristics in Greek multiple sclerosis (MS) patients cohort with bout-onset. Genotypes were determined from 351 patients with clinically definite MS and 375 age- and sex-matched healthy controls. Our results showed no significant differences in the distribution of these polymorphisms between MS patients and controls. Furthermore, stratification for clinical characteristics, such as age at disease onset, clinical course, sex, and severity did not provide significant differences between patients and controls. Together, our findings suggest that IL-1B and IL-1RN gene polymorphisms may not be relevant to the susceptibility to MS or the clinical characteristics of Greek MS patients.
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页码:253 / 257
页数:4
相关论文
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