Molecular MRI of Thrombosis

被引：31
作者：
Ciesienski K.L. [1 ]
Caravan P. [1 ]
机构：
[1] Athinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA, 02129
来源：
Current Cardiovascular Imaging Reports | 2011年 / 4卷 / 1期
基金：
美国国家卫生研究院;
关键词：
Activated platelets; Factor XIII; Fibrin; Gadolinium; Iron oxide; Molecular imaging; MRI; Thrombus;
D O I：
10.1007/s12410-010-9061-5
中图分类号：
学科分类号：
摘要：
This review focuses on recent approaches in using targeted MRI probes for noninvasive molecular imaging of thrombosis. Probe design strategies are discussed: choice of molecular target; nanoparticle versus small-molecule probe; and gadolinium versus iron oxide imaging reporter. Examples of these different design strategies are chosen from the recent literature. Novel contrast agents used to image direct and indirect binding to fibrin have been described as well as direct binding to activated platelets. Emphasis is placed on probes where utility has been demonstrated in animal models or in human clinical trials. © 2010 Springer Science+Business Media, LLC.
引用
收藏
页码：77 / 84
页数：7
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