Effectiveness and molecular interactions of the clinically active mTORC1 inhibitor everolimus in combination with tamoxifen or letrozole in vitro and in vivo

被引:0
作者
Lesley-Ann Martin
Sunil Pancholi
Ian Farmer
Stephanie Guest
Ricardo Ribas
Marion T Weigel
Allan M Thornhill
Zara Ghazoui
Roger A'Hern
Dean B Evans
Heidi A Lane
Stephen R Johnston
Mitch Dowsett
机构
[1] Institute of Cancer Research,Breakthrough Breast Cancer Research Centre
[2] Institute of Cancer Research,McElwain Laboratory
[3] Institute of Cancer Research,Clinical Trial Unit
[4] Novartis Institutes for BioMedical Research,undefined
[5] The Royal Marsden Hospital,undefined
来源
Breast Cancer Research | / 14卷
关键词
Breast Cancer; Estrogen Receptor; Tamoxifen; Everolimus; Letrozole;
D O I
暂无
中图分类号
学科分类号
摘要
引用
收藏
相关论文
共 388 条
[1]  
Ali S(2002)Endocrine-responsive breast cancer and strategies for combating resistance Nat Rev Cancer 2 101-112
[2]  
Coombes RC(2005)ERBB receptors and cancer: the complexity of targeted inhibitors Nat Rev Cancer 5 341-354
[3]  
Hynes NE(2002)Activation of AKT/PKB in breast cancer predicts a worse outcome among endocrine treated patients Br J Cancer 86 540-545
[4]  
Lane HA(2003)Akt kinases in breast cancer and the results of adjuvant therapy Breast Cancer Res 5 R37-44
[5]  
Perez-Tenorio G(2006)The association between Akt activation and resistance to hormone therapy in metastatic breast cancer Eur J Cancer 42 629-635
[6]  
Stal O(2010)Hyperactivation of phosphatidylinositol-3 kinase promotes escape from hormone dependence in estrogen receptor-positive human breast cancer J Clin Invest 120 2406-2413
[7]  
Stal O(2008)ERBB2 influences the subcellular localization of the estrogen receptor in tamoxifen-resistant MCF-7 cells leading to the activation of AKT and RPS6KA2 Endocr Relat Cancer 15 985-1002
[8]  
Perez-Tenorio G(2001)Phosphatidylinositol 3-kinase/AKT-mediated activation of estrogen receptor alpha: a new model for anti-estrogen resistance J Biol Chem 276 9817-9824
[9]  
Akerberg L(2008)AKT alters genome-wide estrogen receptor alpha binding and impacts estrogen signaling in breast cancer Mol Cell Biol 28 7487-7503
[10]  
Olsson B(1998)Rapamycin inhibition of the G1 to S transition is mediated by effects on cyclin D1 mRNA and protein stability J Biol Chem 273 14424-14429