Norovirus detection in wastewater and its correlation with human gastroenteritis: a systematic review and meta-analysis

被引:0
作者
Yue Huang
Nan Zhou
Shihan Zhang
Youqin Yi
Ying Han
Minqi Liu
Yue Han
Naiyang Shi
Liuqing Yang
Qiang Wang
Tingting Cui
Hui Jin
机构
[1] Southeast University,Department of Epidemiology and Health Statistics, School of Public Health
[2] Southeast University,Key Laboratory of Environmental Medicine Engineering, Ministry of Education, School of Public Health
来源
Environmental Science and Pollution Research | 2022年 / 29卷
关键词
Wastewater surveillance; Norovirus; Human gastroenteritis; Detection; Meta-analysis; Systematic review;
D O I
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中图分类号
学科分类号
摘要
Norovirus (NoV) is a major cause of sporadic cases and outbreaks of acute gastroenteritis (AGE), thereby imposing threat to health globally. It is unclear how quantitation of wastewater NoV reflects the incidence of human AGE infections; therefore, we conducted this systematic review and meta-analysis of published NoV wastewater surveillance studies. A literature search was performed, and all studies on NoV wastewater surveillance were identified. Quantitative results were evaluated. The results showed that the overall detection rate of NoV in wastewater was 82.10% (95% confidence interval [CI]: 74.22–89.92%); NoV concentration was statistically significant in terms of season (P < 0.001), with higher concentration in spring and winter. There were positive correlations between NoV GII concentration in wastewater and GII AGE cases (rs = 0.51, 95% CI: 0.18–0.74, I2 = 0%), total AGE cases (rs = 0.40, 95% CI: 0.15–0.61, I2 = 23%) and NoV outbreaks (rs = 0.47, 95% CI: 0.30–0.62, I2 = 0%). Results of cross-correlation analysis of partial data indicated that variations in GII concentration were consistent with or ahead of those in the number of AGE cases. The diversity of NoV genotypes in wastewater was elucidated, and the dominant strains in wastewater showed a consistent temporal distribution with those responsible for human AGE. Our study demonstrated the potential association of NoV detected in wastewater with AGE infections, and further studies are needed to confirm this conclusion.
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页码:22829 / 22842
页数:13
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