Endotoxemic pulmonary hypertension is largely mediated by endothelin-induced venous constriction

[1] Martin M(2005)The decreasing incidence and mortality of acute respiratory distress syndrome after injury: a 5-year observational study J Trauma 59 1107-1113

[2] Salim A(2005)Acute lung injury and the acute respiratory distress syndrome: four decades of inquiry into pathogenesis and rational management Am J Respir Cell Mol Biol 33 319-327

[3] Murray J(1991)Elevated plasma levels of endothelin in patients with sepsis syndrome Circ Shock 33 222-227

[4] Demetriades D(1994)Plasma levels of TNF-alpha, endothelin-1 and thrombomodulin in patients with sepsis Res Commun Chem Pathol Pharmacol 84 261-269

[5] Belzberg H(2006)Endothelin receptor antagonists Pharmacol Ther 110 386-414

[6] Rhee P(1988)Pressor effects of circulating endothelin are limited by its removal in the pulmonary circulation and by the release of prostacyclin and endothelium-derived relaxing factor Proc Natl Acad Sci USA 85 9797-9800

[7] Matthay MA(1996)Pulmonary clearance of circulating endothelin-1 in dogs in vivo: exclusive role of ETB receptors J Appl Physiol 81 1510-1515

[8] Zimmerman GA(2004)Unraveling the mechanism of high altitude pulmonary edema High Alt Med Biol 5 125-135

[9] Weitzberg E(1995)Plasma endothelin-1 levels in human lung transplant recipients J Cardiovasc Pharmacol 26 [Suppl 3] S516-518

[10] Lundberg JM(1999)Effect of meconium aspiration on plasma endothelin-1 level and pulmonary hemodynamics in a piglet model Biol Neonate 76 228-234

[1] Martin M(2005)The decreasing incidence and mortality of acute respiratory distress syndrome after injury: a 5-year observational study J Trauma 59 1107-1113

[2] Salim A(2005)Acute lung injury and the acute respiratory distress syndrome: four decades of inquiry into pathogenesis and rational management Am J Respir Cell Mol Biol 33 319-327

[3] Murray J(1991)Elevated plasma levels of endothelin in patients with sepsis syndrome Circ Shock 33 222-227

[4] Demetriades D(1994)Plasma levels of TNF-alpha, endothelin-1 and thrombomodulin in patients with sepsis Res Commun Chem Pathol Pharmacol 84 261-269

[5] Belzberg H(2006)Endothelin receptor antagonists Pharmacol Ther 110 386-414

[6] Rhee P(1988)Pressor effects of circulating endothelin are limited by its removal in the pulmonary circulation and by the release of prostacyclin and endothelium-derived relaxing factor Proc Natl Acad Sci USA 85 9797-9800

[7] Matthay MA(1996)Pulmonary clearance of circulating endothelin-1 in dogs in vivo: exclusive role of ETB receptors J Appl Physiol 81 1510-1515

[8] Zimmerman GA(2004)Unraveling the mechanism of high altitude pulmonary edema High Alt Med Biol 5 125-135

[9] Weitzberg E(1995)Plasma endothelin-1 levels in human lung transplant recipients J Cardiovasc Pharmacol 26 [Suppl 3] S516-518

[10] Lundberg JM(1999)Effect of meconium aspiration on plasma endothelin-1 level and pulmonary hemodynamics in a piglet model Biol Neonate 76 228-234