Host microbiota constantly control maturation and function of microglia in the CNS

被引：0

作者：

Daniel Erny

Anna Lena Hrabě de Angelis

Diego Jaitin

Peter Wieghofer

Ori Staszewski

Eyal David

Hadas Keren-Shaul

Tanel Mahlakoiv

Kristin Jakobshagen

Thorsten Buch

Vera Schwierzeck

Olaf Utermöhlen

Eunyoung Chun

Wendy S Garrett

Kathy D McCoy

Andreas Diefenbach

Peter Staeheli

Bärbel Stecher

Ido Amit

Marco Prinz

机构：

[1] Institute of Neuropathology,Department of Virology

[2] University of Freiburg,Department of Immunology and Infectious Diseases

[3] Lab for ImmunoGenomics,Department of Clinical Research

[4] Weizmann Institute of Science,undefined

[5] Faculty of Biology,undefined

[6] University of Freiburg,undefined

[7] University of Freiburg,undefined

[8] Institute for Medical Microbiology,undefined

[9] Immunology and Hygiene & Center for Molecular Medicine Cologne (CMMC),undefined

[10] University of Cologne,undefined

[11] Institute for Medical Microbiology,undefined

[12] Immunology,undefined

[13] and Hygiene,undefined

[14] Technische Universität München,undefined

[15] Institute of Medical Microbiology and Hygiene,undefined

[16] University of Mainz Medical Centre,undefined

[17] Harvard School of Public Health,undefined

[18] Mucosal Immunology Lab,undefined

[19] University of Bern,undefined

[20] Max-von-Pettenkofer Institute,undefined

[21] LMU Munich,undefined

[22] German Center for Infection Research (DZIF),undefined

[23] partner site LMU Munich,undefined

[24] BIOSS Centre for Biological Signaling Studies,undefined

[25] University of Freiburg,undefined

来源：

Nature Neuroscience | 2015年 / 18卷

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摘要：

In this study, the authors show that host microbiota play a key role in modulating microglia homeostasis. Germ-free mice or mice with only limited microbiota complexity displayed defects in microglial cell proportions and maturation, leading to impaired innate immune responses. The authors find that short-chain fatty acid signaling regulates these effects in vivo.

引用

页码：965 / 977

页数：12

共 110 条

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