Immune functions in splenectomized thalassaemic children

被引：22

作者：

Ahluwalia J. ^{[1
]}

Datta U. ^{[1
,2
]}

Marwaha R.K. ^{[1
]}

Sehgal S. ^{[1
]}

机构：

[1] Dept. of Immunopathology and Pediat., Postgrad. Inst. Med. Educ. and Res., Chandigarh

[2] Department of Immunopathology, PGIMER

来源：

The Indian Journal of Pediatrics | 2000年 / 67卷 / 12期

关键词：

Splenectomy; Thalassemia Transfusion programme;

D O I：

10.1007/BF02723947

中图分类号：

学科分类号：

摘要：

A prospective study to assess the immune functions in splenectomized thalassaemic children. Children were those registered in the Thalassemia major. There were 10 splenectomized children (Group 1), 10 non-splenectomized children and 6 age-matched control (Group 3). All children were shown to be HIV seronegative. The mean concentrations of serum IgG and IgA were higher in Group 1 as compared to Groups 2 and 3 but the differences were not statistically significant. Nitroblue tetrazolium (NBT) dye reduction by stimulated polymorphonuclear leukocytes was normal in both study and control groups and the differences were not statistically significant. However, NBT reduction in the unstimulated state was much higher in Group 2 as compared to Groups 1 and 3. Phytohaemagglutinin induced mitogen proliferation was normal in all 3 groups. Children in Group 1 not only had a significantly higher absolute lymphocyte count but also had a lower CD4/CD8 ratio as compared to Groups 2 and 3. Splenectomy does appear to alter the immune status of thalassemic children but the exact mechanism by which this occurence is not clear.

引用

页码：871 / 876

页数：5

共 25 条

[1]

Bunn H.F., Disorders of hemoglobin, Harrison's Principles of Internal Medicine, 13th. Edn, pp. 1734-1743, (1994)

[2]

Lukens J.N., The thalassemias and related disorders : Quantitative disorders of hemoglobin synthesis, Wintrobe's Clinical Hematology, 9th. Edn., pp. 1102-1145, (1993)

[3]

Rosse W., Bunn H.F., Hemolytic anemias, Harrison's Principles of Internal Medicine,13th. Edn., pp. 1743-1754, (1994)

[4]

Eraklis H.J., Kevy S.V., Diamond L.K., Hazards of overwhelming infection after splenectomy in children, N Engl J Med, 276, (1967)

[5]

King W., Schumacker Jr. H.B., Susceptibility to infections after splenectomy performed in infancy, Ann Surg, 136, pp. 239-242, (1952)

[6]

Caroline L., Kozinn P., Infection and iron overload in thalassemia, Ann NY Acad Sci, 165, pp. 148-155, (1969)

[7]

Evans H.E., Reindorf C., Serum immunoglobulins in sickle cell disease and thalassemia major, Am J Dis Child, 116, (1968)

[8]

Schumacher M.J., Serum immunoglobulin and transferrin levels after childhood splenectomy, Arch Dis Child, 45, pp. 114-117, (1970)

[9]

Wasi C., Wasi P., Thongcharan P., Serum immunoglobulin levels in thalassemia and the effects of splenectomy, Lancet, 11, pp. 237-239, (1971)

[10]

Seitandis B., Michas A., Angelopoulos B., Serum immunoglobulin levels in beta-thalassemia after splenectomy, Acta Haematol, 46, pp. 267-270, (1971)

← 1 2 3 →