Eugenia jambolana seed extract supplementation attenuates cardiac and hepatic oxidative stress and pathophysiological changes in hypercholesterolemic rats

被引：2

作者：

Sankhari J.M. ^{[1
]}

Jadeja R.N. ^{[1
]}

Thounaojam M.C. ^{[1
]}

Devkar R.V. ^{[1
]}

Ramachandran A.V. ^{[1
]}

机构：

[1] Division of Phytotherapeutics and Metabolic Endocrinology, Department of Zoology, Faculty of Science, The M. S. University of Baroda

来源：

Oriental Pharmacy and Experimental Medicine | 2012年 / 12卷 / 2期

关键词：

Eugenia jambolana; Histopathology; Hyperlipidemia; Oxidative stress;

D O I：

10.1007/s13596-012-0056-4

中图分类号：

学科分类号：

摘要：

The present study was aimed at evaluating protective role of Eugenia jambolana seed extract (EJSE) on high cholesterol diet (HCD) induced hyperlipidemia/hypercholesterolemia amounting to cardiac and hepatic oxidative stress. Serum markers of cardiac and hepatic damage, total lipid profile (serum, tissue and feces), lipid peroxidation, antioxidant status and histopathological changes in cardiac and hepatic tissue have been assessed in control, HCD fed and HCD+EJSE treated (100 mg/kg BW, p. o.) rats. It was observed that co-supplementation of EJSE to HCD fed rats significantly (p < 0. 05) minimized elevation in the serum, and tissue lipid profiles, decrement in the HDL level and resulted in higher elimination of lipids through feces. Also, EJSE successfully ameliorated HCD induced cardiac and hepatic oxidative stress (p < 0. 05) and histopathological damage. It can be concluded that, EJSE has the potential of preventing HCD induced experimental hypercholesterolemia and, related cardiac and hepatic oxidative stress. Its therapeutic potential against HCD induced hypercholesterolemia and subsequent oxidative stress mediated cardiac and hepatic damage is indicated. © 2012 Institute of Oriental Medicine, Kyung Hee University.

引用

页码：99 / 106

页数：7

共 41 条

[1]

Aebi H., Catalase in vivo, Methods Enzymol, 105, pp. 121-126, (1984)

[2]

Ahmed F., Huded S., Malik F.A., In vitro study on the radical scavenging and anti lipid peroxidative effects of Eugenia jambolana aqueous extracts, J Pharm Res, 3, pp. 198-200, (2010)

[3]

Beutler E., Duron O., Kelly B.M., Improved method for the determination of blood glutathione, J Lab Clin Med, 61, pp. 882-888, (1963)

[4]

Buege J.A., Aust S.D., Microsomal lipid peroxidation, Methods Enzymol, 52, pp. 302-310, (1978)

[5]

Cai G.J., Miao C.Y., Xie H.H., Lu L.H., Su D.F., Arterial baroreflex dysfunction promotes atherosclerosis in rats, Atherosclerosis, 183, pp. 41-47, (2005)

[6]

Chang C., Yang M., Wen H., Chern J., Estimation of total flavonoid content in propolis by two complementary colorimetric methods, J Food Drug Analys, 10, pp. 178-182, (2002)

[7]

Chaturvedi A., Bhawani G., Agarwal P.K., Goel S., Singh A., Goel R.K., Antidiabetic and antiulcer effects of extract of Eugenia jambolana seed in mild diabetic rats: Study on gastric mucosal offensive acid-pepsin secretion, Indian J Physiol Pharmacol, 53, pp. 137-146, (2009)

[8]

Deepa P.R., Varalaxmi P., Salubrious effect of low molecular weight heparin on atherogenic diet-induced cardiac, hepatic and renal lipid peroxidation and collapse of antioxidant defenses, Mol Cell Biochem, 254, pp. 111-116, (2003)

[9]

Deepa P.R., Varlakshmi P., Protective effects of certoparin sodium, a low molecular weight heparin derivative, in experimental atherosclerosis, Clin Chim Acta, 339, pp. 105-115, (2004)

[10]

Deepa P.R., Varlakshmi P., Favourable modulation of the inflammatory changes in hypercholesterolemic atherogenesis by a low molecular weight heparin derivative, Int J Cardiol, 106, pp. 338-347, (2006)

← 1 2 3 4 5 →