NF-κB as potential target in the treatment of melanoma

被引：0
作者：
Gabriele Madonna
Claudio Dansky Ullman
Giusy Gentilcore
Giuseppe Palmieri
Paolo Antonio Ascierto
机构：
[1] Istituto Nazionale Tumori Fondazione,Unit of Medical Oncology and Innovative Therapy
[2] G. Pascale,Cancer Therapy Evaluation Program
[3] National Cancer Institute,undefined
[4] Institute of Biomolecular Chemistry-CNR,undefined
来源：
Journal of Translational Medicine | / 10卷
关键词：
NF-κB; Melanoma; NBD peptide; Bortezomib; Curcumin;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
The RAS/MAP kinase pathway has attracted attention because activating mutations of the BRAF serine/threonine kinase was described in over 50% of melanomas. Very recently, selective and potent BRAF inhibitors have been developed. Several other signal transduction pathways have been found to be constitutively active or mutated in other subsets of melanoma tumors that are potentially targetable with new agents. Among these, NFκB is another pathway that melanoma tumors use to achieve survival, proliferation and resistance to apoptosis. Inhibition of NF-κB activation appears to be a very promising option for anti-cancer therapies.
引用
收藏
相关论文
共 324 条
  • [11] Sondak VK(2004)NF-{kappa}B in the Vascular Progression of Melanoma J Clin Oncol 22 617-3883
  • [12] Atkins MB(2002)Identification of gene function and functional pathways by systemic plasmid-based ribozyme targeting in adult mice Proc Natl Acad Sci USA 99 3878-130
  • [13] Eisenhauer EA(2003)Identification of a nuclear factor κ B-dependent gene network Recent Prog Horm Res 58 95-S96
  • [14] Parulekar W(2002)Missing pieces in the NF-κB puzzle Cell 109 S81-663
  • [15] Markovic SN(2000)Phosphorylation meets ubiquitination: the control of NF-κB activity Ann Rev Immunol 18 621-9
  • [16] Saxman S(2000)The I kappa B kinase (IKK) and NF-kappa B: key elements of proinflammatory signalling Semin Immunol 12 85-1499
  • [17] Kirkwood JM(2001)Activation by IKKalpha of a second, evolutionary conserved, NF-kappa B signaling pathway Science 293 1495-80
  • [18] Palmieri G(2004)Comparative expression of NFKB proteins in melanocytes of normal skin vs benign intradermal naevus and human metastatic melanoma biopsies Pigment Cell Res 17 173-1052
  • [19] Capone M(1997)Enhanced Degradation of I-κBα Contributes to Endogenous Activation of NF-κB in Hs294T Melanoma Cells Cancer Res 57 3032-447
  • [20] Ascierto ML(2005)Osteopontin Expression Correlates with Melanoma Invasion J Investig Dermatol 124 1044-1958
12345678910