Highly Selective Ion-Sensitive Electrodes Based on Dibenzo-Crown Ethers Containing Functional Groups for the Determination of Potassium in Biological Fluids

The electrochemical properties of membranes based on dibenzo-crown ethers bearing hydroxyl and chloromethyl groups in polyether rings were studied. These substances were tested as membrane ionophores for ion-selective electrodes (ISEs) reversible to potassium ion. The developed ISEs were used for determining potassium in blood plasma samples. The generalized results of determining potassium in the blood of different patients with cardiovascular diseases revealed quantitative regularities that allowed the diseases to be diagnosed early.