The role of the mitochondrial calcium uniporter (MCU) complex in cancer

被引：0
作者：
Adina Vultur
Christine S. Gibhardt
Hedwig Stanisz
Ivan Bogeski
机构：
[1] Georg-August-University,Molecular Physiology, Institute of Cardiovascular Physiology, University Medical Center
[2] Georg-August-University,Department of Dermatology, Venereology and Allergology, University Medical Center
来源：
Pflügers Archiv - European Journal of Physiology | 2018年 / 470卷
关键词：
Mitochondria; Cancer; MCU; Calcium; ROS; Metabolism; Redox; MICU;
D O I：
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中图分类号：
学科分类号：
摘要：
The important role of mitochondria in cancer biology is gaining momentum. With their regulation of cell survival, metabolism, basic cell building blocks, and immunity, among other functions, mitochondria affect not only cancer progression but also the response and resistance to current treatments. Calcium ions are constantly shuttled in and out of mitochondria; thus, playing an important role in the regulation of various cellular processes. The mitochondrial calcium uniporter (MCU) channel and its associated regulators transport calcium across the inner mitochondrial membrane to the mitochondrial matrix. Due to this central role and the capacity to affect cell behavior and fate, the MCU complex is being investigated in different cancers and cancer-related conditions. Here, we review current knowledge on the role of the MCU complex in multiple cancer types and models; we also provide a perspective for future research and clinical considerations.
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页码：1149 / 1163
页数：14
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  • [1] Ahuja M(2014)The gatekeepers of mitochondrial calcium influx: MICU1 and MICU2 EMBO Rep 15 205-206
  • [2] Muallem S(2013)Altered Ca Biochim Biophys Acta 1835 180-193
  • [3] Akl H(2017) signaling in cancer cells: proto-oncogenes and tumor suppressors targeting IP3 receptors Mol Cell 67 711-723.e7
  • [4] Bultynck G(2009)Systematic identification of MCU modulators by orthogonal interspecies chemical screening Biochim Biophys Acta 1787 1334-1341
  • [5] Arduino DM(2011)The role of Ca(2+) signaling in the coordination of mitochondrial ATP production with cardiac work Nature 476 341-U111
  • [6] Wettmarshausen J(2011)Integrative genomics identifies MCU as an essential component of the mitochondrial calcium uniporter J Am Chem Soc 133 9293-9303
  • [7] Vais H(2011)Calcium binding and transport by coenzyme Q Cell Calcium 50 407-423
  • [8] Navas-Navarro P(2016)Redox regulation of calcium ion channels: chemical and physiological aspects Mol Cell 63 240-248
  • [9] Cheng YM(2004)Redox nanodomains are induced by and control calcium signaling at the ER-mitochondrial interface Am J Phys Cell Phys 287 C817-C833
  • [10] Leimpek A(2008)Calcium, ATP, and ROS: a mitochondrial love-hate triangle Nat Cell Biol 10 1235-1237
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