Spike bursts increase amyloid-β 40/42 ratio by inducing a presenilin-1 conformational change

被引：0

作者：

Iftach Dolev

Hilla Fogel

Hila Milshtein

Yevgeny Berdichevsky

Noa Lipstein

Nils Brose

Neta Gazit

Inna Slutsky

机构：

[1] Sackler Faculty of Medicine,Department of Physiology and Pharmacology

[2] Tel Aviv University,Department of Molecular Neurobiology

[3] Sagol School of Neuroscience,undefined

[4] Tel Aviv University,undefined

[5] Max Planck Institute for Experimental Medicine,undefined

来源：

Nature Neuroscience | 2013年 / 16卷

关键词：

D O I：

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学科分类号：

摘要：

Relative amounts of amyloid-β peptides of different length are altered in the brains of Alzheimer's disease patients. Here the authors show that neuronal patterns differentially regulate the production of amyloid-β isoforms by modifying the molecular conformation of presenilin-1, the catalytic subunit of γ-secretase that cleaves amyloid precursor protein to release amyloid-β.

引用

页码：587 / 595

页数：8

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