Effects of Kampo on functional gastrointestinal disorders

被引：33

作者：

Oka T. ^{[1
]}

Okumi H. ^{[2
]}

Nishida S. ^{[3
]}

Ito T. ^{[4
]}

Morikiyo S. ^{[5
]}

Kimura Y. ^{[6
]}

Murakami M. ^{[7
]}

机构：

[1] Department of Psychosomatic Medicine, Graduate School of Medical Sciences, Kyushu University

[2] Department of Medical Oncology, Division of Psychosomatic Medicine, Kinki University, Faculty of Medicine

[3] Department of Psychosomatic Medicine, JPNese Red Cross Wakayama Medical Center, Wakayama 640-8558

[4] Center of Japanese Oriental Medicine, Kashima Rosai Hospital, Labour Welfare Corporation, Kamisu-shi, Ibaraki 314-0343

[5] Department of Psychosomatic Medicine and Psychiatry, Gujo City Hospital, Hachiman-cho, Gujo City, Gifu 501-4222

[6] Institute of Oriental Medicine, Tokyo Women's Medical University, Kita-ku, Tokyo 114-0014

[7] Department of Psychosomatic Medicine, Nihon University Itabashi Hospital, Itabashi-ku, Tokyo 173-0032

来源：

BioPsychoSocial Medicine | / 8卷 / 1期

关键词：

Functional dyspepsia; Irritable bowel syndrome; Kampo; Keishikashakuyakuto; Rikkunshito;

D O I：

10.1186/1751-0759-8-5

中图分类号：

学科分类号：

摘要：

This article reviews the effectiveness of Kampo (traditional Japanese herbal medicine) in the treatment of functional gastrointestinal disorders, especially functional dyspepsia (FD) and irritable bowel syndrome (IBS). The results of four randomized, controlled trials (RCTs) suggested the usefulness of rikkunshito in relieving the subjective symptoms of patients with FD. Rikkunshito significantly improved not only gastric symptoms, such as epigastiric discomfort, but also extra-gastric symptoms, such as general fatigue, when compared with control drugs. The therapeutic effects of rikkunshito were more evident when it was prescribed to patients with " kyosho", i.e., low energy. Two RCTs suggested the efficacy of keishikashakuyakuto for IBS.Basic research studies have demonstrated that these Kampo medicines have multiple sites of action to improve subjective symptoms. For example, rikkunshito improves gastric motility dysfunction, including impaired adaptive relaxation and delayed gastric emptying, gastric hypersensitivity, and anorexia via facilitation of ghrelin secretion. It also exhibits anti-stress effects, i.e., it attenuates stress-induced exacerbation of gastric sensation and anorexia, as well as the hypothalamic-pituitary-adrenocortical axis and sympathetic activation. Keishikashakuyakuto exhibited not only an antispasmodic effect on intestinal smooth muscle, but also antidepressant-like effects. Case series suggest that other Kampo prescriptions are also effective for FD and IBS. However, further studies are necessary to evaluate their efficacy. © 2014 Oka et al.; licensee BioMed Central Ltd.

引用

共 69 条

[41]

Sato Y., Katagiri F., Itoh H., Takeyama M., Effects of some kampo medicines on plasma levels of neuropeptide Y under venipuncture stress, Biol Pharm Bull, 28, pp. 1757-1761, (2005)

[42]

Tomokane M., Tashiro S., Effect of odor of Kampo medicine, its pharmacokinetics and interaction with modern medicine drugs, Methods Kampo Pharmacol, 1, pp. 110-116, (1997)

[43]

Saegusa Y., Takeda H., Muto S., Nakagawa K., Ohnishi S., Sadakane C., Nahata M., Hattori T., Asaka M., Decreased plasma ghrelin contributes to anorexia following novelty stress, Am J Physiol Endocrinol Metab, 301, (2011)

[44]

Functional dyspepsia, A Guideline for the Diagnosis and Treatment of Psychosomatic Diseases, pp. 42-62, (2006)

[45]

Kawahara H., Kubota A., Hasegawa T., Okuyama H., Ueno T., Ida S., Fukuzawa M., Effects of rikkunshito on the clinical symptoms and esophageal acid exposure in children with symptomatic gastroesophageal reflux, Pediatr Surg Int, 23, pp. 1001-1005, (2007)

[46]

Tominaga K., Iwakiri R., Fujimoto K., Fujiwara Y., Tanaka M., Shimoyama Y., Umegaki E., Higuchi K., Kusano M., Arakawa T., Rikkunshito improves symptoms in PPI-refractory GERD patients: a prospective, randomized, multicenter trial in Japan, J Gastroenterol, 47, pp. 284-292, (2012)

[47]

Kawahara H., Mitani Y., Nomura M., Nose K., Yoneda A., Hasegawa T., Kubota A., Fukuzawa M., Impact of rikkunshito, an herbal medicine, on delayed gastric emptying in profoundly handicapped patients, Pediatr Surg Int, 25, pp. 987-990, (2009)

[48]

Seike J., Sawada T., Kawakita N., Yamamoto Y., Yuasa Y., Yamai H., Takachi H., Yoshida T., Tangoku A., A New Candidate Supporting Drug, Rikkunshito, for the QOL in Advanced Esophageal Cancer Patients with Chemotherapy Using Docetaxel/5-FU/CDDP, Int J Surg Oncol, 2011, (2011)

[49]

Ohno T., Yanai M., Ando H., Toyomasu Y., Ogawa A., Morita H., Ogata K., Mochiki E., Asao T., Kuwano H., Rikkunshito, a traditional Japanese medicine, suppresses cisplatin-induced anorexia in humans, Clin Exp Gastroenterol, 4, pp. 291-296, (2011)

[50]

Oka T., Tamagawa Y., Hayashida S., Kaneda Y., Kodama N., Tsuji S., Rikkunshi-to attenuates adverse gastrointestinal symptoms induced by fluvoxamine, Biopsychosoc Med, 1, (2007)

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