The threat of avian influenza A (H5N1). Part I: epidemiologic concerns and virulence determinants

被引：0
作者：
Jindrich Cinatl
Martin Michaelis
Hans W. Doerr
机构：
[1] Hospital of the Johann Wolfgang Goethe University,Institute for Medical Virology
来源：
Medical Microbiology and Immunology | 2007年 / 196卷
关键词：
Influenza; Influenza Virus; Avian Influenza; H5N1 Virus; Avian Influenza Virus;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Among emerging and re-emerging infectious diseases, influenza constitutes one of the major threats to mankind. In this review series epidemiologic, virologic and pathologic concerns raised by infections of humans with avian influenza virus A/H5N1 are discussed. This first part concentrates on epidemiologic concerns and virulence determinants. H5N1 spread over the world and caused a series of fowl pest outbreaks. Significant human-to-human transmissions have not been observed yet. Mutations that make the virus more compatible with human-to-human transmission may occur at any time. Nevertheless, no one can currently predict with certainty whether H5N1 will become a human pandemic virus.
引用
收藏
页码：181 / 190
页数：9
相关论文
共 504 条
  • [1] Kurtz J(1996)Avian influenza virus isolated from a woman with conjunctivitis Lancet 348 901-902
  • [2] Manvell RJ(1998)Characterisation of an avian influenza A virus isolated from a human—is an intermediate host necessary for the emergence of pandemic influenza viruses? Arch Virol 143 781-787
  • [3] Banks J(1998)Clinical features and rapid viral diagnosis of human disease associated with avian influenza A H5N1 virus Lancet 351 467-471
  • [4] Banks J(2002)Outbreak of avian influenza A(H5N1) virus infection in Hong Kong in 1997 Clin Infect Dis 34 Suppl 2 S58-64
  • [5] Speidel E(2005)Characterization of the 1918 influenza virus polymerase genes Nature 437 889-893
  • [6] Alexander DJ(2005)Avian flu: H5N1 virus outbreak in migratory waterfowl Nature 436 191-192
  • [7] Yuen KY(2005)Highly pathogenic H5N1 influenza virus infection in migratory birds Science 309 1206-339
  • [8] Chan PK(1978)Recent human influenza A (H1N1) viruses are closely related genetically to strains isolated in 1950 Nature 274 334-600
  • [9] Peiris M(2005)Influenza: lessons from past pandemics, warnings from current incidents Nat Rev Microbiol 3 591-1361
  • [10] Tsang DN(2004)Avian influenza A virus (H7N7) associated with human conjunctivitis and a fatal case of acute respiratory distress syndrome Proc Natl Acad Sci USA 101 1356-188
12345678910