Chronic ethanol tolerance as a result of free-choice drinking in alcohol-preferring rats of the WHP line

被引：0
作者：
Wanda Dyr
Ewa Taracha
机构：
[1] Institute of Psychiatry and Neurology,Department of Pharmacology and Physiology of the Central Nervous System
[2] Institute of Psychiatry and Neurology,Department of Neurochemistry
来源：
Pharmacological Reports | 2012年 / 64卷
关键词：
WHP rats; tolerance to the ethanol; chronic drinking of ethanol;
D O I：
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学科分类号：
摘要：
The development of tolerance to alcohol with chronic consumption is an important criterion for an animal model of alcoholism and may be an important component of the genetic predisposition to alcoholism. The aim of this study was to determine whether the selectively bred Warsaw High Preferring (WHP) line of alcohol-preferring rats would develop behavioral and metabolic tolerance during the free-choice drinking of ethanol. Chronic tolerance to ethanol-induced sedation was tested. The loss of righting reflex (LRR) paradigm was used to record sleep duration in WHP rats.
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页码：78 / 83
页数：5
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