Risk for Parkinson’s disease: twin studies for the detection of asymptomatic subjects using [18F]6-fluorodopa PET

被引：0

作者：

A. Laihinen

H. Ruottinen

J. O. Rinne

M. Haaparanta

J. Bergman

O. Solin

M. Koskenvuo

R. Marttila

U. K. Rinne

机构：

[1] Department of Neurology,

[2] University of Turku,undefined

[3] FIN-20520,undefined

[4] Turku,undefined

[5] Finland Tel.: +358 2 2611 700 Fax: +358 2 2611 709,undefined

[6] Turku PET Center,undefined

[7] University of Turku,undefined

[8] Turku,undefined

[9] Finland,undefined

[10] Department of Public Health,undefined

[11] University of Turku,undefined

[12] Turku,undefined

[13] Finland,undefined

来源：

Journal of Neurology | 2000年 / 247卷 / Suppl 2期

关键词：

Key Words Fluorodopa; Heredity; Parkinson’s disease; PET; Twins;

D O I：

10.1007/PL00022911

中图分类号：

学科分类号：

摘要：

Positron emission tomography (PET) studies were carried out with [18F]6-fluorodopa ([18F]6-FD) in monozygotic (MZ) and dizygotic (DZ) twins for the clarification of dopaminergic function. Four MZ and four DZ pairs of twins, each pair consisting of a parkinsonian index case and an asymptomatic co-twin, were collected from the Nationwide Twin Cohort. The control group comprised 14 healthy volunteers. [18F]6-FD PET examinations with a Siemens/CTI 931/08 scanner were performed dynamically over 90 min. The regions-of-interest analysis included the caudate, the putamen and the occipital reference regions. Patlak plots were calculated using occipital tissue input function. The accumulation of [18F]6-FD in the putamen of the asymptomatic co-twins was significantly lower than that in the normal subjects. This result implies that there may be a preclinical stage of Parkinson’s disease in the apparently normal co-twins at the time of the PET study.

引用

页码：110 / 113

页数：3