Regulation of parathyroid function in chronic renal failure

被引：0
作者：
Mariano Rodriguez
Sagrario Cañadillas
Ignacio Lopez
Escolástico Aguilera-Tejero
Yolanda Almaden
机构：
[1] University of Cordoba,Nephrology Service, Research Unit, Hospital Reina Sofia, Department of Medicine, Veterinary School
来源：
Journal of Bone and Mineral Metabolism | 2006年 / 24卷
关键词：
Calcium; Estrogen; Renal Function; Renal Failure; Chronic Kidney Disease;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
This review summarizes the factors involved in the development of hyperparathyroidism secondary (2nd-HPTH) to chronic kidney disease (CKD). Calcium and calcitriol act on their respective specific parathyroid cell receptors to inhibit parathyroid function. As well as the well-known effect of calcium and calcitriol on parathyroid cell function, there is experimental work that demonstrates that phosphate, changes in pH, PTHrP, estrogens, and some cytokines also have an effect on PTH secretion. These factors are relevant in patients with chronic kidney disease. However, low calcium, vitamin D deficiency, and an accumulation of phosphate due to the decrease in renal function are the main pathogenic factors involved in the pathogenesis of 2nd-HPTH in CKD patients.
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页码：164 / 168
页数：4
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