Simultaneous Liver Transplantation and Sleeve Gastrectomy: Prohibitive Combination or a Necessity?

被引:0
作者
Eviatar Nesher
Eytan Mor
Amir Shlomai
Michal Naftaly-Cohen
Renana Yemini
Alexander Yussim
Marius Brown
Andrei Keidar
机构
[1] Rabin Medical Center,The Department of Transplantation
[2] Rabin Medical Center,The Liver Institute
[3] Rabin Medical Center,Department of Medicine D
[4] Rabin Medical Center,Department of General Surgery
[5] Beilinson Hospital,The Department of Surgery
来源
Obesity Surgery | 2017年 / 27卷
关键词
Liver transplantation; Sleeve gastrectomy; Non-alcoholic steatohepatitis; Liver cirrhosis; Bariatric surgery;
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中图分类号
学科分类号
摘要
Previously, many morbidly obese (MO) patients were denied liver transplantation (LT) because of the higher operative risk. However, nowadays, 5 and 10 years graft survival is the rule, and patients whose lives can be prolonged with LT are dying of obesity-related comorbidities. Recent experience suggests that weight reduction in MO liver transplant recipients would improve their long-term survival. The bariatric surgery before LT is contraindicated for patients with decompensated cirrhosis, while post-transplant intervention is associated with increased technical difficulty. We present our experience with three patients who underwent simultaneous liver transplantation and sleeve gastrectomy. After a median 13 months follow-up, all patients are alive, having normal allograft function and significant weight loss. Combined liver transplantation with simultaneous sleeve gastrectomy appears technically feasible and relatively safe in selected patients.
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页码:1387 / 1390
页数:3
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  • [1] Charlton MR(2011)Frequency and outcomes of liver transplantation for nonalcoholic steatohepatitis in the United States Gastroenterology 141 1249-1253
  • [2] Burns JM(2007)Morbid obesity with one or more other serious comorbidities should be a contraindication for liver transplantation Liver Transpl 13 1627-1629
  • [3] Pedersen RA(2008)Bariatric surgery in liver transplant patients: weighing the evidence Obes Surg 18 1515-1516
  • [4] Thuluvath PJ(2015)Bariatric surgery and liver transplantation: a systematic review a new frontier for bariatric surgery Obes Surg 25 134-142
  • [5] Mandell MS(2012)Recurrence of non-alcoholic steatohepatitis and cryptogenic cirrhosis following orthotopic liver transplantation in the context of the metabolic syndrome Clin Transpl 26 E505-E512
  • [6] Zimmerman M(1999)Increased early morbidity and mortality with acceptable long-term function in severely obese patients undergoing liver transplantation Clin Transpl 13 126-130
  • [7] Campsen J(2011)Increased perioperative mortality following bariatric surgery among patients with cirrhosis Clin Gastroenterol Hepatol 9 897-901
  • [8] Lazzati A(2008)Pharmacokinetics of mycophenolic acid, tacrolimus and sirolimus after gastric bypass surgery in end-stage renal disease and transplant patients: a pilot study Clin Transpl 22 281-291
  • [9] Iannelli A(2013)Combined liver transplantation and gastric sleeve resection for patients with medically complicated obesity and end­stage liver disease Am J Transplant 13 363-368
  • [10] Schneck AS(2016)Combined liver transplantation and sleeve gastrectomy for end-stage liver disease in a bariatric patient: First European case-report Int J Surg Case Rep 28 38-41