Synthesis of fused tetracycles from the nitration products of benzo[b]thieno[2,3-c]pyridines

被引：0

作者：

Tolkunov S.V. ^{[1
]}

Kal'nitskii M.N. ^{[1
]}

Lyashchuk S.N. ^{[1
]}

Dulenko V.I. ^{[1
]}

机构：

[1] L. M. Litvinenko Institute of Physical Organic and Coal Chemistry, National Academy of Sciences of Ukraine

来源：

Chemistry of Heterocyclic Compounds | 1997年 / 33卷 / 3期

关键词：

Organic Chemistry; Pyridine; Alkaloid; Force Field; Nitration;

D O I：

10.1007/BF02253117

中图分类号：

学科分类号：

摘要：

The nitration products of benzo[b]thieno[2,3-c]pyridines were used in the synthesis of new fused tetracyclic heterocyclic systems, which are structural analogs of natural ellipticine and olivicine alkaloids. Closure of the pyridine ring gives products only with linear ring fusion. This behavior was explained using the steric strain - stability principle and complete optimization of the structure of these products with a PCMODEL program and MMX force field in conjunction with the π-electron approximation. ©1997 Plenum Publishing Corporation.

引用

页码：346 / 351

页数：5