Zoonotic origin of the human malaria parasite Plasmodium malariae from African apes

被引:0
|
作者
Lindsey J. Plenderleith
Weimin Liu
Yingying Li
Dorothy E. Loy
Ewan Mollison
Jesse Connell
Ahidjo Ayouba
Amandine Esteban
Martine Peeters
Crickette M. Sanz
David B. Morgan
Nathan D. Wolfe
Markus Ulrich
Andreas Sachse
Sébastien Calvignac-Spencer
Fabian H. Leendertz
George M. Shaw
Beatrice H. Hahn
Paul M. Sharp
机构
[1] Institute of Evolutionary Biology and Centre for Immunity,Department of Medicine
[2] Infection and Evolution,Department of Microbiology
[3] University of Edinburgh,Recherche Translationnelle Appliquée au VIH et aux Maladies Infectieuses, Institut de Recherche pour le Développement
[4] University of Pennsylvania,Department of Anthropology
[5] University of Pennsylvania,undefined
[6] University of Montpellier,undefined
[7] INSERM,undefined
[8] Washington University in St. Louis,undefined
[9] Wildlife Conservation Society,undefined
[10] Congo Program,undefined
[11] BP,undefined
[12] Lester E. Fisher Center for the Study and Conservation of Apes,undefined
[13] Lincoln Park Zoo,undefined
[14] Metabiota Inc,undefined
[15] Robert Koch Institute,undefined
[16] Helmholtz Institute for One Health,undefined
来源
Nature Communications | / 13卷
关键词
D O I
暂无
中图分类号
学科分类号
摘要
The human parasite Plasmodium malariae has relatives infecting African apes (Plasmodium rodhaini) and New World monkeys (Plasmodium brasilianum), but its origins remain unknown. Using a novel approach to characterise P. malariae-related sequences in wild and captive African apes, we found that this group comprises three distinct lineages, one of which represents a previously unknown, highly divergent species infecting chimpanzees, bonobos and gorillas across central Africa. A second ape-derived lineage is much more closely related to the third, human-infective lineage P. malariae, but exhibits little evidence of genetic exchange with it, and so likely represents a separate species. Moreover, the levels and nature of genetic polymorphisms in P. malariae indicate that it resulted from the zoonotic transmission of an African ape parasite, reminiscent of the origin of P. falciparum. In contrast, P. brasilianum falls within the radiation of human P. malariae, and thus reflects a recent anthroponosis.
引用
收藏
相关论文
共 50 条
  • [41] The aspartic proteinase from the rodent parasite Plasmodium berghei as a potential model for plasmepsins from the human malaria parasite, Plasmodium falciparum
    Humphreys, MJ
    Moon, RP
    Klinder, A
    Fowler, SD
    Rupp, K
    Bur, D
    Ridley, RG
    Berry, C
    FEBS LETTERS, 1999, 463 (1-2) : 43 - 48
  • [43] New vectors in northern Sarawak, Malaysian Borneo, for the zoonotic malaria parasite, Plasmodium knowlesi
    Ang, Joshua X. D.
    Kadir, Khamisah A.
    Mohamad, Dayang S. A.
    Matusop, Asmad
    Divis, Paul C. S.
    Yaman, Khatijah
    Singh, Balbir
    PARASITES & VECTORS, 2020, 13 (01)
  • [44] Plasmodium cynomolgi in humans: current knowledge and future directions of an emerging zoonotic malaria parasite
    Foko, Loick P. Kojom
    Kumar, Amit
    Hawadak, Joseph
    Singh, Vineeta
    INFECTION, 2023, 51 (03) : 623 - 640
  • [45] Expression and characterization of human malaria parasite Plasmodium falciparum origin recognition complex subunit 1
    Mehra, P
    Biswas, AK
    Gupta, A
    Gourinath, S
    Chitnis, CE
    Dhar, SK
    BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2005, 337 (03) : 955 - 966
  • [46] New vectors in northern Sarawak, Malaysian Borneo, for the zoonotic malaria parasite, Plasmodium knowlesi
    Joshua X. D. Ang
    Khamisah A. Kadir
    Dayang S. A. Mohamad
    Asmad Matusop
    Paul C. S. Divis
    Khatijah Yaman
    Balbir Singh
    Parasites & Vectors, 13
  • [47] Plasmodium cynomolgi in humans: current knowledge and future directions of an emerging zoonotic malaria parasite
    Loick P. Kojom Foko
    Amit Kumar
    Joseph Hawadak
    Vineeta Singh
    Infection, 2023, 51 : 623 - 640
  • [48] Genome sequence of the human malaria parasite Plasmodium falciparum
    Malcolm J. Gardner
    Neil Hall
    Eula Fung
    Owen White
    Matthew Berriman
    Richard W. Hyman
    Jane M. Carlton
    Arnab Pain
    Karen E. Nelson
    Sharen Bowman
    Ian T. Paulsen
    Keith James
    Jonathan A. Eisen
    Kim Rutherford
    Steven L. Salzberg
    Alister Craig
    Sue Kyes
    Man-Suen Chan
    Vishvanath Nene
    Shamira J. Shallom
    Bernard Suh
    Jeremy Peterson
    Sam Angiuoli
    Mihaela Pertea
    Jonathan Allen
    Jeremy Selengut
    Daniel Haft
    Michael W. Mather
    Akhil B. Vaidya
    David M. A. Martin
    Alan H. Fairlamb
    Martin J. Fraunholz
    David S. Roos
    Stuart A. Ralph
    Geoffrey I. McFadden
    Leda M. Cummings
    G. Mani Subramanian
    Chris Mungall
    J. Craig Venter
    Daniel J. Carucci
    Stephen L. Hoffman
    Chris Newbold
    Ronald W. Davis
    Claire M. Fraser
    Bart Barrell
    Nature, 2002, 419 : 498 - 511
  • [49] Genome sequence of the human malaria parasite Plasmodium falciparum
    Gardner, MJ
    Hall, N
    Fung, E
    White, O
    Berriman, M
    Hyman, RW
    Carlton, JM
    Pain, A
    Nelson, KE
    Bowman, S
    Paulsen, IT
    James, K
    Eisen, JA
    Rutherford, K
    Salzberg, SL
    Craig, A
    Kyes, S
    Chan, MS
    Nene, V
    Shallom, SJ
    Suh, B
    Peterson, J
    Angiuoli, S
    Pertea, M
    Allen, J
    Selengut, J
    Haft, D
    Mather, MW
    Vaidya, AB
    Martin, DMA
    Fairlamb, AH
    Fraunholz, MJ
    Roos, DS
    Ralph, SA
    McFadden, GI
    Cummings, LM
    Subramanian, GM
    Mungall, C
    Venter, JC
    Carucci, DJ
    Hoffman, SL
    Newbold, C
    Davis, RW
    Fraser, CM
    Barrell, B
    NATURE, 2002, 419 (6906) : 498 - 511
  • [50] The genome of the simian and human malaria parasite Plasmodium knowlesi
    A. Pain
    U. Böhme
    A. E. Berry
    K. Mungall
    R. D. Finn
    A. P. Jackson
    T. Mourier
    J. Mistry
    E. M. Pasini
    M. A. Aslett
    S. Balasubrammaniam
    K. Borgwardt
    K. Brooks
    C. Carret
    T. J. Carver
    I. Cherevach
    T. Chillingworth
    T. G. Clark
    M. R. Galinski
    N. Hall
    D. Harper
    D. Harris
    H. Hauser
    A. Ivens
    C. S. Janssen
    T. Keane
    N. Larke
    S. Lapp
    M. Marti
    S. Moule
    I. M. Meyer
    D. Ormond
    N. Peters
    M. Sanders
    S. Sanders
    T. J. Sargeant
    M. Simmonds
    F. Smith
    R. Squares
    S. Thurston
    A. R. Tivey
    D. Walker
    B. White
    E. Zuiderwijk
    C. Churcher
    M. A. Quail
    A. F. Cowman
    C. M. R. Turner
    M. A. Rajandream
    C. H. M. Kocken
    Nature, 2008, 455 : 799 - 803