Influence of aminophylline on the anticonvulsive action of gabapentin in the mouse maximal electroshock seizure threshold model

被引：0
|
作者：
J. J. Luszczki
K. Jankiewicz
M. Jankiewicz
S. J. Czuczwar
机构：
[1] Medical University of Lublin,Department of Pathophysiology
[2] Institute of Agricultural Medicine,Department of Physiopathology
[3] Medical University of Lublin,Second Department of Gynecology
[4] Medical University of Lublin,Department of Human Physiology
来源：
Journal of Neural Transmission | 2007年 / 114卷
关键词：
Keywords: Aminophylline; gabapentin; maximal electroshock seizure threshold test; pharmacodynamic interaction; chimney test;
D O I：
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中图分类号：
学科分类号：
摘要：
Accumulating evidence indicates that aminophylline [theophylline2 · ethylenediamine] markedly attenuates the anticonvulsant action of conventional antiepileptic drugs in experimental animal models of epilepsy and evokes severe seizure activity in patients treated with this methylxanthine.
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页码：1539 / 1545
页数：6
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