Death receptor 6 negatively regulates oligodendrocyte survival, maturation and myelination

被引:0
作者
Sha Mi
Xinhua Lee
Yinghui Hu
Benxiu Ji
Zhaohui Shao
Weixing Yang
Guanrong Huang
Lee Walus
Kenneth Rhodes
Bang Jian Gong
Robert H Miller
R Blake Pepinsky
机构
[1] Biogen Idec,Department of Neurosciences
[2] Center for Translational Neuroscience,undefined
[3] Case Western Reserve University School of Medicine,undefined
来源
Nature Medicine | 2011年 / 17卷
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学科分类号
摘要
The multiple sclerosis brain shows massive demyelination. Now, Sha Mi and colleagues show that upregulation of DR6 in multiple sclerosis brain is responsible for inhibiting remyelination and brain repair by oligodendrocytes.
引用
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页码:816 / 821
页数:5
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