Iron and inflammation: cross-talk between pathways regulating hepcidin

[1] Wang RH(2005)A role of SMAD4 in iron metabolism through the positive regulation of hepcidin expression Cell Metab 2 399-409

[2] Li C(2007)Iron transferrin regulates hepcidin synthesis in primary hepatocyte culture through hemojuvelin and BMP2/4 Blood 110 2182-2189

[3] Xu X(2008)Dorsomorphin inhibits BMP signals required for embryogenesis and iron metabolism Nat Chem Biol 4 33-41

[4] Zheng Y(2007)The distal location of the iron responsive region of the hepcidin promoter Blood 110 3436-3437

[5] Xiao C(2005)Hemojuvelin is essential for dietary iron sensing, and its mutation leads to severe iron overload J Clin Invest 115 2180-2186

[6] Zerfas P(2004)An Hfe-dependent pathway mediates hyposideremia in response to lipopolysaccharide-induced inflammation in mice Nat Genet 36 481-485

[7] Lin L(2004)The IL-6- and lipopolysaccharide-induced transcription of hepcidin in HFE-, transferrin receptor 2-, and beta 2-microglobulin-deficient hepatocytes Proc Natl Acad Sci U S A 101 9263-9265

[8] Valore EV(2004)Increased hepcidin expression and hypoferraemia associated with an acute phase response are not affected by inactivation of HFE Br J Haematol 126 434-436

[9] Nemeth E(2006)Distinct requirements for Hfe in basal and induced hepcidin levels in iron overload and inflammation Am J Physiol Gastrointest Liver Physiol 291 G229-G237

[10] Goodnough JB(2006)The iron efflux protein ferroportin regulates the intracellular growth of Salmonella enterica Infect Immun 74 3065-3067

[1] Wang RH(2005)A role of SMAD4 in iron metabolism through the positive regulation of hepcidin expression Cell Metab 2 399-409

[2] Li C(2007)Iron transferrin regulates hepcidin synthesis in primary hepatocyte culture through hemojuvelin and BMP2/4 Blood 110 2182-2189

[3] Xu X(2008)Dorsomorphin inhibits BMP signals required for embryogenesis and iron metabolism Nat Chem Biol 4 33-41

[4] Zheng Y(2007)The distal location of the iron responsive region of the hepcidin promoter Blood 110 3436-3437

[5] Xiao C(2005)Hemojuvelin is essential for dietary iron sensing, and its mutation leads to severe iron overload J Clin Invest 115 2180-2186

[6] Zerfas P(2004)An Hfe-dependent pathway mediates hyposideremia in response to lipopolysaccharide-induced inflammation in mice Nat Genet 36 481-485

[7] Lin L(2004)The IL-6- and lipopolysaccharide-induced transcription of hepcidin in HFE-, transferrin receptor 2-, and beta 2-microglobulin-deficient hepatocytes Proc Natl Acad Sci U S A 101 9263-9265

[8] Valore EV(2004)Increased hepcidin expression and hypoferraemia associated with an acute phase response are not affected by inactivation of HFE Br J Haematol 126 434-436

[9] Nemeth E(2006)Distinct requirements for Hfe in basal and induced hepcidin levels in iron overload and inflammation Am J Physiol Gastrointest Liver Physiol 291 G229-G237

[10] Goodnough JB(2006)The iron efflux protein ferroportin regulates the intracellular growth of Salmonella enterica Infect Immun 74 3065-3067