Correlation between PCNA expression and AgNOR dots in pituitary adenomas

被引:0
作者
Mariusz Klencki
Ilona Kurnatowska
Dorota Słowińska-Klencka
Andrzej Lewiński
Marek Pawlikowski
机构
[1] Medical University of Łódź,Department of Thyroidology, Institute of Endocrinology
[2] Medical University of Łódź,Department of Experimental Endocrinology and Hormonal Diagnostics, Institute of Endocrinology
来源
Endocrine Pathology | 2001年 / 12卷
关键词
Pituitary adenoma; PCNA; nucleolar organizer regions; immunohistochemistry;
D O I
暂无
中图分类号
学科分类号
摘要
Nucleolar organizer regions are segments of DNA associated with argyrophilic proteins (AgNORs). Our previous findings showed that the number, the area, and the intranuclear localization of AgNOR dots differ according to tumor aggressiveness and to the hormone-immunopositivity of pituitary adenomas. Proliferating cell nuclear antigen (PCNA) is a nuclear protein, whose expression is correlated with cell proliferation. The aim of the present paper was to examine PCNA-labeling indexes in pituitary adenomas and to correlate them with AgNOR dots in various immunohistochemical types of the tumors.
引用
收藏
页码:163 / 169
页数:6
相关论文
共 115 条
  • [1] Derenzini M(1994)AgNOR proteins as a parameter of the rapidity of cell proliferation Zentralbl Pathol 140 7-10
  • [2] Trere D(2000)Silver-staining nucleolar organizer region quantification in pituitary adenomas Endocr Pathol 11 173-178
  • [3] Słowińska-Klencka D(1993)Significance of proliferating cell nuclear antigen index in predicting pituitary adenoma recurrence J Neurosurg 78 753-761
  • [4] Klencki M(1996)Flow cytometric DNA ploidy and cells phase fractions in recurrent human pituitary adenomas. A correlative study of flow cytometric analysis and the expression of proliferating cell nuclear antigen Gen Diagn Pathol 142 89-95
  • [5] Dedecjus M(1995)Analysis of the growth rate and cavernous sinus invasion of pituitary adenomas Acta Neurochir 136 37-43
  • [6] Lewiński A(1995)Biologic markers of invasive pituitary adenomas involving the sphenoid sinus Mod Pathol 8 160-164
  • [7] Pawlikowski M(1997)A comparison of proliferation indices in human anterior pituitary adenomas using formalin-fixed tissue and in vitro cell culture J Neurosurg 87 85-88
  • [8] Hsu DW(2000)Vergleichende untersuchungen zur biologischen bedeutung der proliferationsmarker Ki-67-antigen und PCNA in primaren ovarialkarzinomen Zentralbl Gynakol 122 361-367
  • [9] Hakim F(1997)Proliferating cell nuclear antigen and MIB-1. An alternative to classic prognostic indicators in renal cell carcinomas? Am J Clin Pathol 107 229-235
  • [10] Biller BM(1993)Critical analysis of the methods commonly employed in the assessment of cell proliferation: advantages of the NOR silver-staining technique in routine cyto-histopathology Anal Cell Pathol 5 191-201