Correlation between PCNA expression and AgNOR dots in pituitary adenomas

被引：0
作者：
Mariusz Klencki
Ilona Kurnatowska
Dorota Słowińska-Klencka
Andrzej Lewiński
Marek Pawlikowski
机构：
[1] Medical University of Łódź,Department of Thyroidology, Institute of Endocrinology
[2] Medical University of Łódź,Department of Experimental Endocrinology and Hormonal Diagnostics, Institute of Endocrinology
来源：
Endocrine Pathology | 2001年 / 12卷
关键词：
Pituitary adenoma; PCNA; nucleolar organizer regions; immunohistochemistry;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Nucleolar organizer regions are segments of DNA associated with argyrophilic proteins (AgNORs). Our previous findings showed that the number, the area, and the intranuclear localization of AgNOR dots differ according to tumor aggressiveness and to the hormone-immunopositivity of pituitary adenomas. Proliferating cell nuclear antigen (PCNA) is a nuclear protein, whose expression is correlated with cell proliferation. The aim of the present paper was to examine PCNA-labeling indexes in pituitary adenomas and to correlate them with AgNOR dots in various immunohistochemical types of the tumors.
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页码：163 / 169
页数：6
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