Neutral endopeptidase/CD10 and aminopeptidase N/CD13 gene expression as a prognostic factor in non-small cell lung cancer

被引：36
作者：
Tokuhara T. [2 ,3 ]
Adachi M. [3 ]
Hashida H. [3 ]
Ishida H. [3 ]
Taki T. [3 ]
Higashiyama M. [1 ]
Kodama K. [1 ]
Tachibana S. [2 ]
Sasaki S. [2 ]
Miyake M. [3 ]
机构：
[1] Department of Surgery, The Center for Adult Diseases of Osaka, Osaka
[2] Department of Thoracic Surgery, Osaka Medical College, Osaka
[3] Department of Thoracic Sirgery and Department V of Oncology, Kitano Hospital, Tazuke Kofukai Medical Research Institute, Osaka, 530-8480, 13-3 Kamiyamacho, Kita-ku
来源：
The Japanese Journal of Thoracic and Cardiovascular Surgery | 2001年 / 49卷 / 8期
关键词：
NEP/CD10; APN/CD13; lung cancer; prognosis; RT-PCR;
D O I：
10.1007/BF02919543
中图分类号：
学科分类号：
摘要：
OBJECTIVES: Neutral endopeptidase modulates the growth of lung cancer, while aminopeptidase N degrades the extracellular matrix and is involved in cell motility. We studied the metastasis mechanism to detect novel metastasis-associated molecules and to evaluate them for clinical application. METHODS: We studied the relationship between the expression of neutral endopeptidase and aminopeptidase N by quantitative reverse transcript-polymerase chain reaction analysis in 132 patients with non-small cell lung cancer undergoing radical surgery from 1991 to 1996. RESULTS: Patients with neutral endopeptidase-positive and aminopeptidase N-negative tumors were defined as group A, those with neutral endopeptidase-positive and aminopeptidase N-positive or neutral endopeptidase-negative and aminopeptidase N-negative tumors as group B, and those with neutral endopeptidase-negative and aminopeptidase N-positive tumors as group C. The 5-year survival of group A patients (92.9%) was significantly better than that of group B patients (64.7%) and much better than that of group C patients (38.2%) (P = 0.0011). Neutral endopeptidase and aminopeptidase N thus have statistically significant P in overall survival in Cox regression (P = 0.019). CONCLUSION: Neutral endopeptidase and aminopeptidase N gene expressions are significant indicators of prognosis.
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页码：489 / 496
页数：7
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