SDF-1alpha G801A polymorphism in Southern Iranian patients with colorectal and gastric cancers

被引：13
作者：
Razmkhah M. [1 ]
Ghaderi A. [1 ]
机构：
[1] Shiraz Institute for Cancer Research, Department of Immunology, School of Medicine, Shiraz University of Medical Sciences, 1798 Shiraz
来源：
Indian Journal of Gastroenterology | 2013年 / 32卷 / 1期
关键词：
Cancer susceptibility; Chemokine; Single nucleotide polymorphism;
D O I：
10.1007/s12664-012-0283-0
中图分类号：
学科分类号：
摘要：
Background: A single nucleotide polymorphism (SNP) in the stromal cell-derived factor-1 (SDF-1) gene at position 801 (G>A) is associated with susceptibility to certain tumors. This study aimed to investigate an association between this SNP and colorectal and gastric cancers in an Iranian population. Method: Genotype and allele frequencies of SDF-1 801 G>A were assessed using polymerase chain reaction-restriction fragment length polymorphism in 109 patients with colorectal cancer, 124 with gastric cancer, and 262 normal control volunteers. Results: No statistically significant difference was observed in the frequencies of genotypes and alleles between patients and controls (p & 0. 05). Conclusion: SDF-1 gene polymorphism at position 801 (G>A) was not associated with colorectal and gastric cancers in Southern Iranian patients. © 2012 Indian Society of Gastroenterology.
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页码：28 / 31
页数：3
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共 30 条
  • [1] Selgrad M., Bornschein J., Rokkas T.H., Malfertheiner P., Clinical aspects of gastric cancer and Helicobacter pylori-screening, prevention, and treatment, Helicobacter, 15, pp. 40-45, (2010)
  • [2] Marcus B., Arenberg D., Lee J., Et al., Prognostic factors in oral cavity and oropharyngeal squamous cell carcinoma, Cancer, 101, pp. 2779-2787, (2004)
  • [3] Uchida D., Begum N.M., Tomizuka Y., Et al., Acquisition of lymph node, but not distant metastatic potentials, by the overexpression of CXCR4 in human oral squamous cell carcinoma, Lab Invest, 84, pp. 1538-1546, (2004)
  • [4] Razmkhah M., Talei A.R., Doroudchi M., Khalili-Azad T., Ghaderi A., Stromal cell-derived factor-1 (SDF-1) alleles and susceptibility to breast carcinoma, Cancer Lett, 225, pp. 261-266, (2005)
  • [5] Khademi B., Razmkhah M., Erfani N., Gharagozloo M., Ghaderi A., SDF-1 and CCR5 genes polymorphism in patients with head and neck cancer, Pathol Oncol Res, 14, pp. 45-50, (2008)
  • [6] Razmkhah M., Doroudchi M., Ghayumi S.M., Erfani N., Ghaderi A., Stromal cell-derived factor-1 (SDF-1) gene and susceptibility of Iranian patients with lung cancer, Lung Cancer, 49, pp. 311-315, (2005)
  • [7] Bleul C.C., Fuhlbrigge R.C., Casasnovas J.M., Aiuti A., Springer T.A., A highly efficacious lymphocyte chemoattractant, stromal cell-derived factor 1 (SDF-1), J Exp Med, 184, pp. 1101-1109, (1996)
  • [8] Sun X., Cheng G., Hao M., Et al., CXCL12/CXCR4/CXCR7 chemokine axis and cancer progression, Cancer Metastasis Rev, 29, pp. 709-722, (2010)
  • [9] Perissinotto E., Cavalloni G., Leone F., Et al., Involvement of chemokine receptor 4/stromal cell-derived factor 1 system during osteosarcoma tumor progression, Clin Cancer Res, 11, pp. 490-497, (2005)
  • [10] Luker K.E., Luker G.D., Functions of CXCL12 and CXCR4 in breast cancer, Cancer Lett, 23, pp. 1-12, (2005)
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