The role of food allergy in atopic dermatitis

被引:0
作者
Pia J. Hauk
机构
[1] National Jewish Medical and Research Center,Department of Pediatrics
来源
Current Allergy and Asthma Reports | 2008年 / 8卷
关键词
Atopic Dermatitis; Food Allergy; Allergy Clin Immunol; Food Allergen; House Dust Mite;
D O I
暂无
中图分类号
学科分类号
摘要
Atopic dermatitis (AD) is a chronic, pruritic, inflammatory skin disease affecting more than 10% of all children. Sensitization to foods triggers isolated skin symptoms in about 30% of children. These symptoms include immediate reactions within minutes after ingesting food without exacerbation of AD and early and late exacerbations of AD. It is important to identify clinically relevant sensitizations to foods using skin prick tests, a specific IgE blood test (ImmunoCAP; Phadia, Portage, MI, USA), and double-blind, placebo-controlled food challenges to initiate appropriate dietary interventions and avoid unnecessary dietary restrictions. Children with AD triggered by food allergens demonstrate a distinct immune response upon stimulation of their peripheral blood mononuclear cells with food allergen. A defective skin barrier and increased intestinal permeability appear to facilitate allergen sensitization. Appropriate skin care to maintain skin barrier function and dietary avoidance of highly allergenic foods during infancy may help to prevent allergen sensitization, thereby reducing the severity of AD and food allergies.
引用
收藏
相关论文
共 139 条
[1]  
Leung D.Y.M.(2004)New insights into atopic dermatitis J Clin Invest 113 651-657
[2]  
Boguniewicz M.(1999)Worldwide variations in the prevalence of symptoms of atopic eczema in the International Study of Asthma and Allergies in Childhood J Allergy Clin Immunol 103 125-138
[3]  
Howell M.D.(1997)Atopic eczema: its impact on the family and financial cost Arch Dis Child 76 159-162
[4]  
Williams H.(2006)Does food allergy cause atopic dermatitis? Food challenge testing to dissociate eczematous from immediate reactions Dermatol Ther 19 97-103
[5]  
Robertson C.(1999)Food hypersensitivity and atopic dermatitis: pathophysiology, epidemiology, diagnosis, and management J Allergy Clin Immunol 104 S114-S122
[6]  
Stewart A.(1999)Food allergy, I: immunopathogenesis and clinical disorders J Allergy Clin Immunol 103 717-728
[7]  
Su J.C.(2004)Update on food allergy J Allergy Clin Immunol 113 805-819
[8]  
Kemp A.S.(1998)Food-induced cutaneous adverse reactions Allergy 53 131-135
[9]  
Varigos G.A.(2004)Role of food allergy in atopic dermatitis Curr Opin Allergy Clin Immunol 4 379-385
[10]  
Nolan T.M.(1998)Atopic dermatitis and food hypersensitivity reactions J Pediatr 132 132-136