Synthesis and biological evaluation of 2,4-disubstituted thiazole amide derivatives as anticancer agent

被引：0

作者：

Zhi-Hua Zhang

Hong-Mei Wu

Sai-Nan Deng

Rui-Xia Chai

Muriira Cyrus Mwenda

Yuan-Yuan Peng

Dong Cai

Yu Chen

机构：

[1] Liaoning University of Technology,School of Chemical and Environmental Engineering

[2] Jinzhou Medical University,College of Pharmacy

[3] Jinzhou Medical University,College of Basic Science

[4] Shenyang Pharmaceutical University,School of Life Science and Biopharmaceutics

来源：

Chemical Papers | 2019年 / 73卷

关键词：

Thiazole derivatives; Synthesis; Anticancer activity;

D O I：

暂无

中图分类号：

学科分类号：

摘要：

A series of novel 2,4-disubstituted thiazole amide derivatives were synthesized, and their antiproliferative activities were tested. Some of these compounds displayed good antiproliferative activity, especially for HT29 cell. Among these compounds, compound 5b inhibits A549, HeLa, HT29 and Karpas299 cells with IC50 values of 8.64, 6.05, 0.63 and 13.87 μM, respectively. The western blot analysis and docking study provide important clues for further optimization of compound 5b as a potential c-Met inhibitor.

引用

页码：355 / 364

页数：9

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