Development and immunological assessment of VLP-based immunogens exposing the membrane-proximal region of the HIV-1 gp41 protein

被引:0
作者
Thomas D Benen
Paul Tonks
Alexander Kliche
Ruth Kapzan
Jonathan L Heeney
Ralf Wagner
机构
[1] Institute of Medical Microbiology and Hygiene,Molecular Microbiology and Gene Therapy Unit
[2] University of Regensburg,Department of Veterinary Medicine
[3] University of Cambridge,undefined
[4] Malvern Instruments GmbH,undefined
[5] GeneArt AG / LifeTechnologies Inc,undefined
来源
Journal of Biomedical Science | / 21卷
关键词
HIV-1; gp41; VLPs; Vaccine; Immunization study; Neutralizing antibodies;
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[1]  
Stephenson KE(2013)A global approach to HIV-1 vaccine development Immunol Rev 254 295-304
[2]  
Barouch DH(2009)Neutralizing antibodies against HIV-1: can we elicit them with vaccines and how much do we need? Curr Opin HIV AIDS 4 347-351
[3]  
Montefiori DC(2009)Effective, low-titer antibody protection against low-dose repeated mucosal SHIV challenge in macaques Nat Med 15 951-954
[4]  
Mascola JR(2009)Broad neutralization of human immunodeficiency virus type 1 mediated by plasma antibodies against the gp41 membrane proximal external region J Virol 83 11265-11274
[5]  
Hessell AJ(1998)HIV entry and its inhibition Cell 93 681-684
[6]  
Poignard P(1997)Atomic structure of the ectodomain from HIV-1 gp41 Nature 387 426-430
[7]  
Hunter M(2012)Broad and potent neutralization of HIV-1 by a gp41-specific human antibody Nature 491 406-412
[8]  
Hangartner L(2007)Exposure of the membrane-proximal external region of HIV-1 gp41 in the course of HIV-1 envelope glycoprotein-mediated fusion Biochemistry 46 1398-1401
[9]  
Tehrani DM(2008)HIV-1 broadly neutralizing antibody extracts its epitope from a kinked gp41 ectodomain region on the viral membrane Immunity 28 52-63
[10]  
Bleeker WK(2005)Broadly Neutralizing Anti-HIV Antibody 4E10 Recognizes a Helical Conformation of a Highly Conserved Fusion-Associated Motif in gp41 Immunity 22 163-173