Therapeutic strategies to eliminate breast cancer stem cells

被引：0
作者：
Ann H. Klopp
Wendy A. Woodward
机构：
[1] The University of Texas M.D. Anderson Cancer Center,Department of Radiation Oncology
来源：
Current Breast Cancer Reports | 2009年 / 1卷 / 4期
关键词：
Breast Cancer; Mammary Gland; Cancer Stem Cell; Lapatinib; Stem Cell Population;
D O I：
10.1007/s12609-009-0031-3
中图分类号：
学科分类号：
摘要：
Recent studies have identified markers that can be used to prospectively identify cells with a tumor-initiating phenotype when transplanted into the cleared fat pads of immunocompromised mice. The technical capability to identify cells that meet the functional criteria of putative cancer stem cells has led to investigations of their biological importance and an expanding interest in developing therapeutic strategies to target the stem cell population. It is believed that strategies targeting cancer stem cells may complement traditional therapies, which are effective at eliminating the rapidly proliferating differentiated population but less effective at treating the cancer stem cell populations, which may then seed metastasis or local recurrence. This article reviews potential targets and targeting strategies for selective cancer stem cell therapies.
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页码：222 / 228
页数：6
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