The Advent of Spatial Omics in Congenital Heart Disease

被引：0
作者：
Traeger G.R. [1 ]
Jaatinen K.J. [2 ]
Majesky M.W. [1 ]
Greene C.L. [2 ,3 ]
机构：
[1] Department of Pediatrics, Center for Developmental Biology and Regenerative Medicine, Seattle Children’s Research Institute, University of Washington, Seattle, WA
[2] Division of Cardiac Surgery, Seattle Children’s Hospital, University of Washington, 4800 Sand Point Way NE, RC 2.820, Seattle, 98105, WA
[3] Center for Integrative Brain Research, Seattle Children’s Research Institute, University of Washington, Seattle, WA
来源：
Current Treatment Options in Pediatrics | 2023年 / 9卷 / 4期
关键词：
Cardiac genetics; Cardiac transcriptomics; Coarctation of the aorta; Congenital heart disease; Spatial biology; Spatial omics;
D O I：
10.1007/s40746-023-00282-1
中图分类号：
学科分类号：
摘要：
Purpose of Review: Spatial omics is a transformative technology which will impact multiple areas of clinical medicine over the next decade. The goal of this review is to acquaint the pediatric clinician with the emerging field of Spatial omics by discussing the impact of this technology on the prototypical congenital heart defect: coarctation of the aorta. We will discuss how current methodologies have struggled to adequately elucidate the mechanism of this lesion and how Spatial omics may allow for better delineation of the pathobiology of this quintessential congenital heart defect. Recent Findings: Several genes are implicated in the development of coarctation of the aorta including NOTCH1, FOXC1, and MYH6. Despite being first described nearly 200 years ago and first surgically repaired nearly 90 years ago, there is no known unifying mechanism for the development of this common congenital heart defect. The advent of Spatial omics has the potential to help clinical scientists understand the causal pathway for this lesion and many other congenital heart defects. Summary: Spatial omics is a transformative technology that will have broad impact across multiple sub-specialties. The coming flood of information has promise to change how we view the origin, progression, and treatment of many diseases and disorders whose pathology remains enigmatic. © 2023, The Author(s), under exclusive licence to Springer Nature Switzerland AG.
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页码：302 / 313
页数：11
相关论文
共 68 条
  • [1] Bressan D., Battistoni G., Hannon G.J., The dawn of spatial omics, Science., 381, (2023)
  • [2] Palla G., Fischer D.S., Regev A., Theis F.J., Spatial components of molecular tissue biology, Nat Biotechol, 40, pp. 308-318, (2022)
  • [3] Lu T., Ang C.E., Zhuang X., Spatially resolved epigenomic profiling of single cells in complex tissues, Cell, 185, pp. 4448-44464, (2022)
  • [4] Roth R., Kim S., Kim J., Rhee S., Single-cell and spatial transcriptomics approaches of cardiovascular development and disease, BMB Rep, 53, pp. 393-399, (2020)
  • [5] Crick F., Central dogma of molecular biology, Nature, 227, pp. 561-563, (1970)
  • [6] Barba M., Czosnek H., Hadidi A., Historical perspective, development and applications of next-generation sequencing in plant virology, Viruses, 6, pp. 106-136, (2014)
  • [7] Slatko B.E., Gardner A.F., Ausubel F.M., Overview of next generation sequencing technologies, Curr Protoc Mol Biol, 122, (2018)
  • [8] van Dijk E.L., Auger H., Jaszczyszyn Y., Thermes C., Ten years of next-generation sequencing technology, Trends Genet, 30, pp. 418-426, (2014)
  • [9] Endrullat C., Glokler J., Franke P., Frohme M., Standardization and quality management in next-generation sequencing, Appl Transl Genom, 10, pp. 2-9, (2016)
  • [10] Podnar J., Deiderick H., Huerta G., Hunicke-Smith S., Next-generation sequencing RNA-Seq library construction, Curr Protoc Mol Biol, 106, (2014)
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