From blobology" to the atomic resolution of cryo-electron microscopy

被引：0

作者：

Stark H. ^{[1
]}

机构：

[1] Abteilung Strukturelle Dynamik, Max-Planck-Institut für biophysikalische Chemie, Am Fassberg 11, Göttingen

来源：

BIOspektrum | 2020年 / 26卷 / 7期

关键词：

D O I：

10.1007/s12268-020-1480-5

中图分类号：

学科分类号：

摘要：

It took almost a century to develop electron microscopy into a powerful method for high-resolution structure determination of proteins. Technical improvements in microscopy, detector technology, and image processing software contributed to the exponential growth of high-resolution structures of protein complexes determined by cryo-electron microscopy in recent years. We now succeeded in breaking another resolution barrier in cryo-electron microscopy and for the first time in achieving true atomic resolution, where single atoms in the protein can indeed be visualized individually. These improvements in cryo-EM indicate that the method will continue to gain importance, not only as a method for structure determination but also in the development of new drugs in pharmaceutical research. © 2020, Der Autor.

引用

页码：710 / 713

页数：3

共 9 条

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