The role of glucocorticoid, interleukin-1β, and antioxidants in prenatal stress effects on embryonic microglia

被引：0
作者：
Jada Bittle
Hanna E. Stevens
机构：
[1] University of Iowa Carver College of Medicine,Department of Psychiatry
[2] University of Iowa,Interdisciplinary Graduate Program in Neuroscience
[3] University of Iowa Carver College of Medicine,Iowa Neuroscience Institute
来源：
Journal of Neuroinflammation | / 15卷
关键词：
Prenatal stress; Embryonic brain; Microglia; Corticosterone; Interleukin-1β; Antioxidant;
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摘要：
Maternal stress during pregnancy is associated with an increased risk of psychopathology in offspring. Resident immune cells of the brain, microglia, may be mediators of prenatal stress and altered neurodevelopment. Here, we demonstrate that neither the exogenous pro-inflammatory cytokine, interleukin-1β (IL-1β), nor the glucocorticoid hormone, corticosterone, recapitulated the full effects of prenatal stress on the morphology of microglial cells in the cortical plate of embryonic mice; IL-1β effects showed greater similarity to prenatal stress effects on microglia. Unexpectedly, oil vehicle alone, which has antioxidant properties, moderated the effects of prenatal stress on microglia. Microglia changes with prenatal stress were also sensitive to the antioxidant, N-acetylcysteine, suggesting redox dysregulation as a mechanism of prenatal stress.
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