Tissue transglutaminase mRNA expression in apoptotic cell death

被引：0
|
作者：
E. B. Volokhina
R. Hulshof
C. Haanen
I. Vermes
机构：
[1] Medisch Spectrum Twente,Department of Clinical Chemistry
[2] Hospital Group,undefined
来源：
Apoptosis | 2003年 / 8卷
关键词：
apoptosis; cultured cells; mononuclear cells; myelodysplastic syndrome; necrosis; real-time RT-PCR; tissue transglutaminase mRNA expression;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Introduction: Tissue transglutaminase (t.TG) is an enzyme that catalyzes the cross-linking of intracellular proteins, thus assembling a protein scaffold that prevents leakage of intracellular components. t.TG is activated during the apoptotic cell death cascade and plays a key role in the formation of apoptotic bodies. The aim of this study was to determine to what amount t.TG-mRNA becomes expressed during apoptosis and whether the t.TG-mRNA expression level could be used as trace marker of recent apoptosis and in individual cases for quantification of apoptosis.
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页码：673 / 679
页数：6
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