Simultaneous Population Pharmacokinetic Model for Lopinavir and Ritonavir in HIV-Infected Adults

被引：0
作者：
José Moltó
Manuel José Barbanoj
Cristina Miranda
Asunción Blanco
José Ramón Santos
Eugenia Negredo
Joan Costa
Pere Domingo
Bonaventura Clotet
Marta Valle
机构：
[1] Hospital Universitari Germans Trias i Pujol,“Lluita contra la SIDA” Foundation
[2] Universidad Autonóma de Barcelona,Centre d’Investigació del Medicament
[3] Institut de Recerca de l’Hospital de la Santa Creu i Sant Pau,“IrsiCaixa” Foundation
[4] Hospital Universitari Germans Trias i Pujol,Department of Clinical Pharmacology
[5] Hospital Universitari Germans Trias i Pujol,Department of Internal Medicine
[6] Hospital de la Santa Creu i Sant Pau,Fundació Lluita contra la SIDA
[7] Hospital Universitari Germans Trias i Pujol,undefined
来源：
Clinical Pharmacokinetics | 2008年 / 47卷
关键词：
Ritonavir; Lopinavir; Population Pharmacokinetic Model; Objective Function Value; Advanced Liver Fibrosis;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Background: Lopinavir is a protease inhibitor indicated for the treatment of HIV infection. It is coformulated with low doses of ritonavir in order to enhance its pharmacokinetic profile. After oral administration, plasma concentrations of lopinavir can vary widely between different HIV-infected patients.
引用
收藏
页码：681 / 692
页数：11
相关论文
共 121 条
[51]  
Goicoechea M.(undefined)undefined undefined undefined undefined-undefined
[52]  
Witt M.D.(undefined)undefined undefined undefined undefined-undefined
[53]  
Sterling R.(undefined)undefined undefined undefined undefined-undefined
[54]  
Lissen E.(undefined)undefined undefined undefined undefined-undefined
[55]  
Clumeck N.(undefined)undefined undefined undefined undefined-undefined
[56]  
Droste J.A.H.(undefined)undefined undefined undefined undefined-undefined
[57]  
Aarnoutse R.E.(undefined)undefined undefined undefined undefined-undefined
[58]  
Koopmans P.P.(undefined)undefined undefined undefined undefined-undefined
[59]  
Jonsson E.N.(undefined)undefined undefined undefined undefined-undefined
[60]  
Karlsson M.O.(undefined)undefined undefined undefined undefined-undefined
12345678910