Cocaine, reward, movement and monoamine transporters

被引：0
作者：
Uhl G.R. [1 ]
Hall F.S. [1 ]
Sora I. [1 ,2 ]
机构：
[1] Molecular Neurobiology Branch, NIDA-IRP, NIH, Baltimore
[2] Psychopharmacology Laboratory, Tokyo Metropolitan Institute of Psychiatry, Tokyo
来源：
Molecular Psychiatry | 2002年 / 7卷 / 1期
关键词：
Aversion; Cocaine; Knockout mouse; Polygenic; Reinforcement; Reward;
D O I：
10.1038/sj.mp.4000964
中图分类号：
学科分类号：
摘要：
Recent evidence enriches our understanding of the molecular sites of action of cocaine reward and locomotor stimulation. Dopamine transporter blockade by cocaine appears a sufficient explanation for cocaine-induced locomotion. Variation in DAT appears to cause differences in locomotion without drug stimulation. However, previously-held views that DAT blockade was the sole site for cocaine reward have been replaced by a richer picture of multitransporter involvement with the rewarding and aversive actions of cocaine. These new insights, derived from studies of knockout mice with simultaneous deletions and/or blockade of multiple transporters, provide a novel model for the rewarding action of this heavily-abused substance and implicate multiple monoamine systems in cocaine's hedonic activities. © 2002 Nature Publishing Group All rights reserved.
引用
收藏
页码：21 / 26
页数：5
相关论文
共 103 条
[1]  
Johanson C.E., Fischman M.W., The pharmacology of cocaine related to its abuse, Pharmacol Rev, 41, pp. 3-52, (1989)
[2]  
Gawin F.H., Cocaine addiction: Psychology and neurophysiology, Science, 251, pp. 1580-1586, (1991)
[3]  
Satel S.L., Southwick S.M., Gawin F.H., Clinical features of cocaine induced paranoia, NIDA Res Monogr, 105, (1991)
[4]  
Kuhar M.J., Ritz M.C., Boja J.W., The dopamine hypothesis of the reinforcing properties of cocaine, Trends Neurosci, 14, pp. 299-302, (1991)
[5]  
Spealman R.D., Madras B.K., Bergman J., Effects of cocaine and related drugs in nonhuman primates II. Stimulant effects on schedule-controlled behavior, J Pharmacol Exp Ther, 251, pp. 142-149, (1989)
[6]  
Ritz M.C., Lamb R.J., Goldberg S.R., Kuhar M.J., Cocaine receptors on dopamine transporters are related to self-administration of cocaine, Science, 237, pp. 1219-1223, (1987)
[7]  
Kuhar M.J., Ritz M.C., Sharkey J., Cocaine receptors on dopamine transporters mediate cocaine-reinforced behavior, NIDA Res Monogr, 88, pp. 14-22, (1988)
[8]  
Ritz M.C., Lamb R.J., Goldberg S.R., Kuhar M.J., Cocaine self-administration appears to be mediated by dopamine uptake inhibition, Prog Neuropsychopharmacol Biol Psychiatry, 12, pp. 233-239, (1988)
[9]  
Roberts D.C., Corcoran M.E., Fibiger H.C., On the role of ascending catecholaminergic systems in intravenous self-administration of cocaine, Pharmacol Biochem Behav, 6, pp. 615-620, (1977)
[10]  
Roberts D.C., Koob G.F., Klonoff P., Fibiger H.C., Extinction and recovery of cocaine self-administration following 6-hydroxydopamine lesions of the nucleus accumbens, Pharmacol Biochem Behav, 12, pp. 781-787, (1980)
12345678910