Translational medicine for acute lung injury

被引：0
作者：
Jianguo Zhang
Yumeng Guo
Michael Mak
Zhimin Tao
机构：
[1] Jiangsu University,Department of Emergency Medicine, The Affiliated Hospital
[2] Jiangsu University,Jiangsu Key Laboratory of Medical Science and Laboratory Medicine, Department of Laboratory Medicine, School of Medicine
[3] Yale University,Department of Biomedical Engineering, School of Engineering and Applied Science
[4] Jiangsu University,Zhenjiang Key Laboratory of High Technology Research on Exosomes Foundation and Transformation Application, School of Medicine
来源：
Journal of Translational Medicine | / 22卷
关键词：
Acute lung injury; Acute respiratory distress syndrome; Animal model; Nanomedicine; Drug delivery; Therapy;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Acute lung injury (ALI) is a complex disease with numerous causes. This review begins with a discussion of disease development from direct or indirect pulmonary insults, as well as varied pathogenesis. The heterogeneous nature of ALI is then elaborated upon, including its epidemiology, clinical manifestations, potential biomarkers, and genetic contributions. Although no medication is currently approved for this devastating illness, supportive care and pharmacological intervention for ALI treatment are summarized, followed by an assessment of the pathophysiological gap between human ALI and animal models. Lastly, current research progress on advanced nanomedicines for ALI therapeutics in preclinical and clinical settings is reviewed, demonstrating new opportunities towards developing an effective treatment for ALI.
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