Single-nucleotide polymorphisms and expression of IL23R in Chinese ankylosing spondylitis patients

被引：0
作者：
Xinwei Wang
Jinxian Huang
Zhiming Lin
Zetao Liao
Chao Li
Qiujing Wei
Yingjuan Jiang
Like Zhao
Jieruo Gu
机构：
[1] Third Affiliated Hospital of Sun Yat-Sen University,Department of Rheumatology
来源：
Rheumatology International | 2010年 / 30卷
关键词：
Ankylosing spondylitis; IL23R; Single-nucleotide polymorphism; Chinese;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
The aim of this study was to investigate the association of single-nucleotide polymorphisms (SNPs) in IL23R with ankylosing spondylitis (AS) in Chinese Han population. Six SNPs were selected for analysis in AS patients and controls. The IL23R mRNA expression was detected using RT-PCR. The differences in the genotypes of rs11209032 and the differences in the genotypes and allele frequencies of rs6677188 between cases and controls were significant. The two SNPs rs11209032 and rs6677188 were in strong linkage disequilibrium. Haplotype analysis noted a higher proportion of GAC in cases and a higher proportion of GTC in controls. The patients with AS showed an elevated level of IL23R mRNA in PBMCs. This study suggested that IL23R polymorphisms were associated with susceptibility to AS in the Chinese population and that IL23R may be involved in the development of AS.
引用
收藏
页码：955 / 959
页数：4
相关论文
共 120 条
[1]  
Brown MA(1997)Susceptibility to ankylosing spondylitis in twins: the role of genes, HLA, and the environment Arthritis Rheum 40 1823-1828
[2]  
Kennedy LG(2004)The interleukin 1 gene cluster contains a major susceptibility locus for ankylosing spondylitis Am J Hum Genet 75 587-595
[3]  
MacGregor AJ(2000)Polymorphisms of the CYP2D6 gene increase susceptibility to ankylosing spondylitis Hum Mol Genet 9 1563-1566
[4]  
Darke C(2003)Novel genetic markers in the 5′-flanking region of ANKH are associated with ankylosing spondylitis Arthritis Rheum 48 791-797
[5]  
Duncan E(2003)The IL-12 family of heterodimeric cytokines: new players in the regulation of T-cell responses Immunity 19 641-644
[6]  
Shatford JL(2002)A receptor for the heterodimeric cytokine IL-23 is composed of IL-12Rβ1 and a novel cytokine receptor subunit, IL-23R J Immunol 168 5699-5708
[7]  
Timms AE(2002)IL-23 and IL-12 have overlapping, but distinct effects on murine dendritic cells J Immunol 168 5448-5454
[8]  
Crane AM(2006)Identification and expression analysis of alternatively spliced isoforms of human interleukin-23 receptor gene in normal lymphoid cells and selected tumor cells Immunogenetics 57 934-943
[9]  
Sims AM(2007)IL23R variation determines susceptibility but not disease phenotype in inflammatory bowel disease Gastroenterology 132 1657-1664
[10]  
Cordell HJ(2007)Sequence variants in the genes for the interleukin-23 receptor (IL23R) and its ligand (IL12B) confer protection against psoriasis Hum Genet 122 201-206
12345678910