5-HT2 receptor antagonist-mediated inhibition of halothane-induced contractures in skeletal muscle specimens from malignant hyperthermia susceptible patients

被引：0

作者：

F. Wappler

J. Scholz

M. Fiege

A. Richter

M. Steinfath

R. Weißhorn

J. Schulte am Esch

机构：

[1] Department of Anaesthesiology,

[2] University Hospital Eppendorf,undefined

[3] Martinistrasse 52,undefined

[4] D-20246 Hamburg,undefined

[5] Germany,undefined

[6] Department of Pharmacology,undefined

[7] Toxicology and Pharmacy,undefined

[8] School of Veterinary Medicine,undefined

[9] Bünteweg 17,undefined

[10] D-30559 Hannover,undefined

[11] Germany,undefined

来源：

Naunyn-Schmiedeberg's Archives of Pharmacology | 1999年 / 360卷

关键词：

In vitro contracture test Halothane Caffeine 5-HT Ritanserin Skeletal muscle;

D O I：

暂无

中图分类号：

学科分类号：

摘要：

Administration of 5-HT2 receptor agonists induced malignant hyperthermia (MH) in susceptible pigs. Furthermore, the 5-HT2 receptor antagonist ritanserin prevented 5-HT-induced porcine MH. It has been shown that 5-HT2 receptor agonists induce marked contractures in skeletal muscle specimens from MH susceptible (MHS) but not in specimens from normal patients. The purpose of this study was to investigate the effects of ritanserin on halothane-induced contractures in muscle specimens from MHS patients.

引用

页码：376 / 381

页数：5