Gout and Hyperuricemia: an Historical Perspective

被引:0
作者
C. Ronald MacKenzie
机构
[1] Hospital for Special Surgery,Department of Rheumatology and Medicine, The C Ronald MacKenzie Chair in Ethics and Medicine
[2] Weill Medical College of Cornell University,Clinical Medicine and Medical Ethics
关键词
Gout; Hyperuricemia; Colchicum; Hippocrates; Sydenham; Garrod;
D O I
10.1007/s40674-015-0012-9
中图分类号
学科分类号
摘要
Gout is a common disorder of uric acid metabolism. A disease of antiquity its’ often dramatic presentation and unique manifestations have been familiar for eons to clinicians and to its sufferers. Effective modern therapies may have downgraded its status, yet it’s long, rich history remains a source of fascination, indeed entertainment to those with an interest in the pathophysiology of disease, therapeutic discovery, indeed with the annals of medicine. This paper reviews the history of one of the oldest afflictions of mankind.
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页码:119 / 130
页数:11
相关论文
共 43 条
  • [1] Kittredge WE(1952)The role of gout in the formation of urinary calculi J Urol 67 841-5
  • [2] Downs R(2006)A concise history of gout and hyperuricemia and their treatment Arthr Res Ther 8 1-87
  • [3] Nuki G(1943)Milestones in the diagnosis and treatment of gout Arch Int Med 72 377-18
  • [4] Simkin PA(1970)A historical note: Leeuvenhoek’s description of crystals from a gouty tophus Arthritis Rheum 13 414-84
  • [5] Neuwirth E(1964)A familial disorder of uric acid metabolism and central nervous system function Am J Med 36 561-39
  • [6] McCarty DJ(1967)Enzyme defect associated with a sex-linked human neurological disorder and excessive purine synthesis Science 155 1682-00
  • [7] Lesch M(1967)A specific enzyme defect in gout associated with overproduction of uric acid Proc Natl Acad Sci U S A 57 1735-65
  • [8] Nyhan WL(1972)Accelerated erythrocyte 5′-phosphor-ribosylpyrophosphate synthesis. A familial abnormality associated with excessive uric acid production and gout Biochem Med 6 310-40
  • [9] Seegmiler JE(1954)History and the use of colchicum and related medications in gout Ann Rheum Dis 13 190-06
  • [10] Rosenbloom FM(1970)The early history of antirheumatic drugs Arthrit Rheum 13 145-43