Immunoregulatory soluble CTLA-4 modifies effector T-cell responses in systemic lupus erythematosus

被引:0
作者
Lekh N. Dahal
Neil Basu
Hazem Youssef
Rahul C. Khanolkar
Robert N. Barker
Lars P. Erwig
Frank J. Ward
机构
[1] University of Aberdeen,Section of Immunology and Infection, Division of Applied Medicine, Institute of Medical Sciences
[2] Aberdeen Royal Infirmary,Department of Rheumatology
[3] Aberdeen Royal Infirmary,Renal Unit
[4] University of Southampton,Antibody and Vaccine Group, Cancer Sciences Unit, Faculty of Medicine
[5] Southampton General Hospital,undefined
[6] GSK,undefined
[7] Experimental Medicine Unit,undefined
[8] Immunoinflammation TA,undefined
[9] Medicines Research Centre,undefined
来源
Arthritis Research & Therapy | / 18卷
关键词
Soluble CTLA-4; Systemic lupus erythematosus; Immune regulation;
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  • [21] Datta SK(2000)B and T cell immune response to small nuclear ribonucleoprotein particles in lupus mice: autoreactive CD4(+) T cells recognize a T cell epitope located within the RNP80 motif of the 70K protein Eur J Immunol 30 2191-200
  • [22] Rosen A(2001)T cell epitope mapping of the Smith antigen reveals that highly conserved Smith antigen motifs are the dominant target of T cell immunity in systemic lupus erythematosus J Immunol 167 562-8
  • [23] Casciola-Rosen L(2002)Interleukin-10-mediated regulatory T-cell responses to epitopes on a human red blood cell autoantigen Blood 100 4529-36
  • [24] Muller S(2013)The soluble isoform of CTLA-4 as a regulator of T-cell responses Eur J Immunol 43 1274-85
  • [25] Monneaux F(2000)Measurement of T-helper cytokines secreted by cord blood mononuclear cells in response to allergens J Immunol Methods 234 13-22
  • [26] Schall N(2010)CTLA-4 is expressed by human monocyte-derived dendritic cells and regulates their functions Hum Immunol 71 934-41
  • [27] Rashkov RK(2013)The engagement of CTLA-4 on primary melanoma cell lines induces antibody-dependent cellular cytotoxicity and TNF-alpha production J Transl Med 11 108-5876-11-108-11
  • [28] Oparanov BA(2014)Pituitary expression of CTLA-4 mediates hypophysitis secondary to administration of CTLA-4 blocking antibody Sci Transl Med 6 230ra45-3
  • [29] Wiesel P(2003)Gough SC. Association of the T-cell regulatory gene CTLA4 with susceptibility to autoimmune disease Nature 423 506-55
  • [30] Geiger JM(2005)Lack of correlation between the levels of soluble cytotoxic T-lymphocyte associated antigen-4 (CTLA-4) and the CT-60 genotypes J Autoimmune Dis 2 8-44