A Portrait of the Bcl-2 Protein Family: Life, Death, and the Whole Picture

被引：0
作者：
Marc Pellegrini
Andreas Strasser
机构：
[1] The Walter and Eliza Hall Institute of Medical Research,
来源：
Journal of Clinical Immunology | 1999年 / 19卷
关键词：
Bcl-2 family of proteins; apoptosis; cancer; autoimmunity; infection;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
The Bcl-2 family of proteins are important regulators of cell death. They are comprised of two opposing factions, the proapoptotic versus the antiapoptotic members. Both are required for normal development and cellular homeostasis of the immune system and other tissues. However, in certain circumstances they may participate in the development of disease.
引用
收藏
页码：365 / 377
页数：12
相关论文
共 931 条
  • [81] Gu Y(1997)Cloning of a Proc Natl Acad Sci USA 94 3668-3672
  • [82] Taya C(1999) homologue by interaction with adenovirus E1B 19K Mol Cell 3 287-296
  • [83] Karasuyama H(1997)Bok is a pro-apoptotic Bcl-2 protein with restricted expression in reproductive tissues and heterodimerizes with selective anti-apoptotic Bcl-2 family members J Biol Chem 272 24101-24104
  • [84] Yoshida H(1994)Mtd, a novel Bcl-2 family member activates apoptosis in the absence of heterodimerization with Bcl-2 and Bcl-x Cell 79 189-192
  • [85] Kong YY(1994)Bad, a heterodimeric partner for Bcl-x Nature 369 321-323
  • [86] Yoshida R(1998) and Bcl-2, displaces Bax and promotes cell death Proc Natl Acad Sci USA 95 4386-4391
  • [87] Elia AJ(1998)Bik, a novel death-inducing protein shares a distinct sequence motif with Bcl-2 family proteins and interacts with viral and cellular survival-promoting proteins J Biol Chem 273 5841-5845
  • [88] Hakem A(1997)BID: A novel BH3 domain-only death agonist Science 275 1122-1126
  • [89] Hakem R(1999)Harakiri, a novel regulator of cell death, encodes a protein that activates apoptosis and interacts selectively with survival-promoting proteins Bcl-2 and Bcl-X(L) Nature 399 411-412
  • [90] Cecconi F(1998)Molecular cloning of a novel polypeptide, DP5, induced during programmed neuronal death Science 281 1309-1312
45678910111213