A Portrait of the Bcl-2 Protein Family: Life, Death, and the Whole Picture

被引:0
作者
Marc Pellegrini
Andreas Strasser
机构
[1] The Walter and Eliza Hall Institute of Medical Research,
来源
Journal of Clinical Immunology | 1999年 / 19卷
关键词
Bcl-2 family of proteins; apoptosis; cancer; autoimmunity; infection;
D O I
暂无
中图分类号
学科分类号
摘要
The Bcl-2 family of proteins are important regulators of cell death. They are comprised of two opposing factions, the proapoptotic versus the antiapoptotic members. Both are required for normal development and cellular homeostasis of the immune system and other tissues. However, in certain circumstances they may participate in the development of disease.
引用
收藏
页码:365 / 377
页数:12
相关论文
共 931 条
  • [1] Kerr JF(1972)Apoptosis: A basic biological phenomenon with wide-ranging implications in tissue kinetics Br J Cancer 26 239-257
  • [2] Wyllie AH(1992)Social controls on cell survival and cell death Nature 356 397-400
  • [3] Currie AR(1999)Cell death in development Cell 96 245-254
  • [4] Raff MC(1994)An evolutionary perspective on apoptosis Cell 76 777-779
  • [5] Vaux DL(1994)Apoptosis and its role in human disease Biotechnology (NY) 12 487-493
  • [6] Korsmeyer SJ(1995)Apoptosis in the pathogenesis and treatment of disease Science 267 1456-1462
  • [7] Vaux DL(1997)The role of the Biochim Biophys Acta 1333 F151-F178
  • [8] Haecker G(1998) gene family in cancer and general implications of defects in cell death control for tumourigenesis and resistance to chemotherapy Science 281 1312-1316
  • [9] Strasser A(1998)Caspases: Enemies within Nature 391 43-50
  • [10] Barr PJ(1998)A caspase-activated DNase that degrades DNA during apoptosis, and its inhibitor ICAD Immunity 8 451-460