Synthesis and antimicrobial evaluation of 4,5-diaryl-2-[4-(t-amino)-2-butynyl]-2,4-dihydro-3H-1,2,4-triazol-3-ones

被引：0

作者：

E. N. Al-kaissi

N. F. Al-Ghrary

N. K. Al-Kaisi

A. Al-Shamma

Z. Muhi-eldeen

机构：

[1] University of Petra,Faculty of Pharmacy

[2] University of Baghdad,College of Pharmacy

[3] Petra University,Department of Pharmacology and Biomedical Sciences, Faculty of Pharmacy

来源：

Medicinal Chemistry Research | 2012年 / 21卷

关键词：

Triazole derivatives; Aminoacetylenic derivatives; Antimicrobial activity; Antifungal activity;

D O I：

暂无

中图分类号：

学科分类号：

摘要：

A series of 4,5-diaryl-2-[4-(t-amino)-2-butynyl]-2,4-dihydro-3H-1,2,4-triazol-3-ones were synthesized and characterized by infrared spectrum (IR), 1H-NMR spectra and elemental analyses. Investigation of their antimicrobial activity was performed. Antimicrobial activity profile of the title compounds were evaluated against Gram- positive bacteria, Gram-negative bacteria and fungi. The synthesized compounds displayed different degrees of antimicrobial activities as shown in Table 3. Compound 12 was the most active one. This may be attributed to 4,5-diphenylsubstituent on the triazoline-3-one ring and the nature of the amino groups at terminal acetylenic moiety.

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页码：3390 / 3395

页数：5

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