Cytotoxic triterpene glycosides from the roots of Sanguisorba officinalis

被引：0
作者：
Jiang Hu
Yan Song
Hui Li
Benshou Yang
Xia Mao
Yongmao Zhao
Xiaodong Shi
机构：
[1] Qujing Normal University,College of Biological Resources and Environment Science
[2] 455 Hospital of People’s Liberation Army,Department of Pharmacy
[3] Qujing Normal University,College of Physics and Electronic Engineering
[4] Qujing Medical College,Institute of Microbiology
来源：
Archives of Pharmacal Research | 2015年 / 38卷
关键词：
Rosaceae; Triterpene glycoside; Cytotoxicity;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Phytochemical investigation of the ethanol extract of the roots of Sanguisorba officinalis resulted in the isolation of three new triterpene glycosides, 3β-[(α-L-arabinopyranosyl)oxy]-19α,23-dihydroxyolean-12-en-28-oic acid 28-[6-O-acetyl-β-D-glucopyranosyl] ester (1), 2α,3β,19α,23-tetrahydroxyurs-12-en-28-oic acid 28-[6-O-acetyl-β-D-glucopyranosyl] ester (2), and 3β-[(α-L-arabinopyranosyl)oxy]-19α-hydroxyurs-12,20(30)-dien-28-oic acid 28-[6-O-acetyl-β-D-glucopyranosyl] ester (3). All the triterpene glycosides exhibited the significant cytotoxic potential with low IC50 values (IC50 < 5.0 μM) against six tumor cell lines (MCF-7, HeLa, HepG2, SGC-7901, NCI-H460, and BGC-823).
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页码：984 / 990
页数：6
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