Complex cytogenetic abnormalities in a patient with chronic myeloid leukemia: a case report

被引：0
作者：
A. S. Lukyanova
B. Pienkowska-Grela
Z. V. Maslyak
机构：
[1] Academy of Medical Sciences of Ukraine,Institute of Blood Pathology and Transfusion Medicine
[2] M. Sklodowska-Curie Memorial Cancer Center and Institute of Oncology,undefined
来源：
Cytology and Genetics | 2009年 / 43卷
关键词：
Chronic Myeloid Leukemia; Interphase Nucleus; Chronic Myeloid Leukemia Patient; Blast Crisis; Metaphase Plate;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
A case of multiple chromosome aberrations in a patient with CML (chronic myeloid leukemia) in the accelerated phase was described. Cytogenetic and molecular genetic studies revealed the presence of a t(9; 22)(q34; q11) translocation and some additional abnormalities such as t(1; 2)(p36; p21), del(6)(q21), +del(8)(q22), del(18)(q21), and +der(22), part of which is not typical for this kind of pathology. The correlation between the obtained data and the data presented in different publications is considered. A probable connection of the detected changes with previously received treatment and a possible effect of these changes on CML progression are discussed.
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页码：188 / 193
页数：5
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