Release of diclofenac sodium from polylactide-co-glycolide 80/20 rods

被引:0
作者
Petrus Viitanen
Esa Suokas
Pertti Törmälä
Nureddin Ashammakhi
机构
[1] Tampere University of Technology,Institute of Biomaterials
[2] Linvatec Biomaterials Ltd.,undefined
来源
Journal of Materials Science: Materials in Medicine | 2006年 / 17卷
关键词
Differential Scanning Calorimetry; Drug Release; UHMWPE; Drug Content; Inherent Viscosity;
D O I
暂无
中图分类号
学科分类号
摘要
Due to inflammatory reactions complicating bioabsorbable devices, the aim of this study was to develop and characterize bioabsorbable implants with anti-inflammatory drug releasing properties. Polylactide-co- glycolide (PLGA) 80/20 was compounded with diclofenac sodium (DS) to produce rods. Thermal properties were analyzed using differential scanning calorimetry (DSC). Inherent viscosity (ηinh) was measured to evaluate the drug effect on the extrude polymer. Drug release measurements were performed using UV-spectrophotometer. Five parallel samples from each type of rods were examined, first at 6 hour intervals, then on daily basis, and later twice a week. DS was released in 110 days from thinner rods and in 150 days from thicker rods. Drug release comprised a starting peak, slow release phase, then a high release phase, and a burst release phase. DSC analysis showed that DS containing rods had crystallinity in their structure. In conclusions, it is feasible to combine PLGA 80/20 and DS by using melt extrusion. Released DS concentrations reached local therapeutic levels, but the release profile was complex and therapeutic levels were not reached all the time.
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页码:1267 / 1274
页数:7
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